Polymer nanomedicines

J Kopeček, J Yang - Advanced drug delivery reviews, 2020 - Elsevier
Polymer nanomedicines (macromolecular therapeutics, polymer-drug conjugates, drug-free
macromolecular therapeutics) are a group of biologically active compounds that are …

Protein PEPylation: a new paradigm of protein–polymer conjugation

Y Hou, H Lu - Bioconjugate Chemistry, 2019 - ACS Publications
Various polymers have been tested for protein conjugation with a goal of bridging the
complementary advantages of both components. However, many of these polymers …

Stimuli-responsive polymer-doxorubicin conjugate: Antitumor mechanism and potential as nano-prodrug

K Chen, H Cai, H Zhang, H Zhu, Z Gu, Q Gong, K Luo - Acta biomaterialia, 2019 - Elsevier
Polymer-drug conjugates has significantly improved the anti-tumor efficacy of
chemotherapeutic drugs and alleviated their side effects. N-(1, 3-dihydroxypropan-2-yl) …

Enzyme-sensitive biodegradable and multifunctional polymeric conjugate as theranostic nanomedicine

H Cai, X Wang, H Zhang, L Sun, D Pan, Q Gong… - Applied materials …, 2018 - Elsevier
In this study, we designed and fabricated a novel amphiphilic biodegradable triblock N-(2-
hydroxypropyl methyl) acrylamide (HPMA) copolymer-gadolinium-paclitaxel-Cyanine5. 5 …

Multistimuli-responsive PEGylated polymeric bioconjugate-based nano-aggregate for cancer therapy

K Chen, S Liao, S Guo, X Zheng, B Wang… - Chemical Engineering …, 2020 - Elsevier
Biocompatible, stimuli-responsive, intelligent and efficient drug delivery systems are
essential for effectively suppressing cancer and reducing toxic side effects of …

Antifouling polymer brushes via oxygen-tolerant surface-initiated PET-RAFT

AR Kuzmyn, AT Nguyen, LW Teunissen, H Zuilhof… - Langmuir, 2020 - ACS Publications
This work presents a new method for the synthesis of antifouling polymer brushes using
surface-initiated photoinduced electron transfer-reversible addition–fragmentation chain …

[HTML][HTML] Biotin-decorated all-HPMA polymeric micelles for paclitaxel delivery

Y Wang, MJ van Steenbergen, N Beztsinna… - Journal of Controlled …, 2020 - Elsevier
To avoid poly (ethylene glycol)-related issues of nanomedicines such as accelerated blood
clearance, fully N-2-hydroxypropyl methacrylamide (HPMAm)-based polymeric micelles …

Enzyme-and pH-sensitive branched polymer–doxorubicin conjugate-based nanoscale drug delivery system for cancer therapy

X Wei, Q Luo, L Sun, X Li, H Zhu, P Guan… - … applied materials & …, 2016 - ACS Publications
Owing to their dendritic architectural features, branched copolymers have been investigated
as drug delivery systems. In this paper, an enzyme-and pH-sensitive branched poly [N-(2 …

HPMA copolymer-based nanomedicines in controlled drug delivery

P Chytil, L Kostka, T Etrych - Journal of Personalized Medicine, 2021 - mdpi.com
Recently, numerous polymer materials have been employed as drug carrier systems in
medicinal research, and their detailed properties have been thoroughly evaluated. Water …

The light at the end of the tunnel—second generation HPMA conjugates for cancer treatment

J Yang, J Kopeček - Current opinion in colloid & interface science, 2017 - Elsevier
It is almost four decades since N-(2-hydroxypropyl) methacrylamide (HPMA)-based
copolymers arose as drug carriers. Although fundamentals have been established and …