Protein PEPylation: a new paradigm of protein–polymer conjugation
Various polymers have been tested for protein conjugation with a goal of bridging the
complementary advantages of both components. However, many of these polymers …
complementary advantages of both components. However, many of these polymers …
Stimuli-responsive polymer-doxorubicin conjugate: Antitumor mechanism and potential as nano-prodrug
Polymer-drug conjugates has significantly improved the anti-tumor efficacy of
chemotherapeutic drugs and alleviated their side effects. N-(1, 3-dihydroxypropan-2-yl) …
chemotherapeutic drugs and alleviated their side effects. N-(1, 3-dihydroxypropan-2-yl) …
Enzyme-sensitive biodegradable and multifunctional polymeric conjugate as theranostic nanomedicine
In this study, we designed and fabricated a novel amphiphilic biodegradable triblock N-(2-
hydroxypropyl methyl) acrylamide (HPMA) copolymer-gadolinium-paclitaxel-Cyanine5. 5 …
hydroxypropyl methyl) acrylamide (HPMA) copolymer-gadolinium-paclitaxel-Cyanine5. 5 …
Multistimuli-responsive PEGylated polymeric bioconjugate-based nano-aggregate for cancer therapy
K Chen, S Liao, S Guo, X Zheng, B Wang… - Chemical Engineering …, 2020 - Elsevier
Biocompatible, stimuli-responsive, intelligent and efficient drug delivery systems are
essential for effectively suppressing cancer and reducing toxic side effects of …
essential for effectively suppressing cancer and reducing toxic side effects of …
Antifouling polymer brushes via oxygen-tolerant surface-initiated PET-RAFT
This work presents a new method for the synthesis of antifouling polymer brushes using
surface-initiated photoinduced electron transfer-reversible addition–fragmentation chain …
surface-initiated photoinduced electron transfer-reversible addition–fragmentation chain …
[HTML][HTML] Biotin-decorated all-HPMA polymeric micelles for paclitaxel delivery
Y Wang, MJ van Steenbergen, N Beztsinna… - Journal of Controlled …, 2020 - Elsevier
To avoid poly (ethylene glycol)-related issues of nanomedicines such as accelerated blood
clearance, fully N-2-hydroxypropyl methacrylamide (HPMAm)-based polymeric micelles …
clearance, fully N-2-hydroxypropyl methacrylamide (HPMAm)-based polymeric micelles …
Enzyme-and pH-sensitive branched polymer–doxorubicin conjugate-based nanoscale drug delivery system for cancer therapy
Owing to their dendritic architectural features, branched copolymers have been investigated
as drug delivery systems. In this paper, an enzyme-and pH-sensitive branched poly [N-(2 …
as drug delivery systems. In this paper, an enzyme-and pH-sensitive branched poly [N-(2 …
HPMA copolymer-based nanomedicines in controlled drug delivery
Recently, numerous polymer materials have been employed as drug carrier systems in
medicinal research, and their detailed properties have been thoroughly evaluated. Water …
medicinal research, and their detailed properties have been thoroughly evaluated. Water …
The light at the end of the tunnel—second generation HPMA conjugates for cancer treatment
It is almost four decades since N-(2-hydroxypropyl) methacrylamide (HPMA)-based
copolymers arose as drug carriers. Although fundamentals have been established and …
copolymers arose as drug carriers. Although fundamentals have been established and …