The cancer stem cell (CSC) concept, which arose more than a decade ago, proposed that
tumor growth is sustained by a subpopulation of highly malignant cancerous cells. These …

Adult stem cells hold many promises for future clinical applications and regenerative
medicine. The haematopoietic stem cell (HSC) is the best-characterized somatic stem cell so …

Regulatory programs that control the function of stem cells are active in cancer and confer
properties that promote progression and therapy resistance. However, the impact of a stem …

Myc is a pleiotropic basic helix–loop–helix leucine zipper transcription factor that
coordinates expression of the diverse intracellular and extracellular programs that together …

Mammalian skin comprises a multi-layered epithelium, the epidermis, and an underlying
connective tissue, the dermis. The epidermal extracellular matrix is a basement membrane …

Sequencing efforts led to the identification of somatic mutations that could affect the self-
renewal and differentiation of cancer-initiating cells. One such recurrent mutation targets the …

The stem cell niche is composed of a specialized population of cells that plays an essential
role in regulating adult stem cell self-renewal and differentiation. In adults, osteoblasts …

Background Malignant gliomas rank among the most lethal cancers. Gliomas display a
striking cellular heterogeneity with a hierarchy of differentiation states. Recent studies …

Lineage-restricted cells can be reprogrammed to a pluripotent state through overexpression
of defined transcription factors. Here, we summarize recent progress in the direct …

The mevalonate synthesis inhibitors, statins, are mainstay therapeutics for cholesterol
management and cardiovascular health. Thirty years of research have uncovered supportive …