For our immune system to contain or eliminate malignant solid tumours, both myeloid and
lymphoid haematopoietic cells must not only extravasate from the bloodstream into the …

Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …

Summary Inflammatory (Ly6C hi CCR2+) monocytes provide defense against infections but
also contribute to autoimmune diseases and atherosclerosis. Monocytes originate from bone …

Background CXCR7 (RDC1), the recently discovered second receptor for CXCL12, is
phylogenetically closely related to chemokine receptors, but fails to couple to G-proteins and …

Trauma is still one of the main reasons for death among the population worldwide. Mortality
occurring early after injury is due to “first hits”, including severe organ injury, hypoxia …

Chemokines, or chemotactic cytokines, and their receptors have been discovered as
essential and selective mediators in leukocyte migration to inflammatory sites and to …

Chemokines and their receptors are key mediators of the inflammatory process regulating
leukocyte extravasation and directional migration into inflamed and infected tissues. The …

A set of chemokine receptors are structurally unable to elicit migration or conventional
signalling responses after ligand engagement. These'silent'(non-signalling) chemokine …

There are several molecular entities common to the immune and nervous systems. Salient
among them are the chemokines and their receptors, which play remarkably varied and …

The Duffy antigen receptor for chemokines (DARC) belongs to a family of'silent'heptahelical
chemokine receptors that do not couple to G proteins and fail to transmit measurable …