Design, synthesis fusidic acid derivatives alleviate acute lung injury via inhibiting MAPK/NF-κB/NLRP3 pathway

Z Liu, X Huang, HY Guo, LW Zhang, YS Quan… - European Journal of …, 2023 - Elsevier
Acute lung injury (ALI) refers to a series of lung lesions resulting from multiple lung injuries,
even leading to morbidity and death, abundant previous reports have showed that anti …

A comprehensive review on the pharmacological role of gut microbiome in neurodegenerative disorders: potential therapeutic targets

N Aziz, P Wal, A Patel, H Prajapati - Naunyn-Schmiedeberg's Archives of …, 2024 - Springer
Neurological disorders, including Alzheimer and Parkinson's, pose significant challenges to
public health due to their complex etiologies and limited treatment options. Recent advances …

[HTML][HTML] The combination of Tanshinone IIA and Astragaloside IV attenuates myocardial ischemia–reperfusion injury by inhibiting the STING pathway

P Zhai, Q Chen, X Wang, X Ouyang, M Yang, Y Dong… - Chinese Medicine, 2024 - Springer
Abstract Background Astragaloside IV (As-IV) and Tanshinone IIA (Ta-IIA) are the main
ingredients of traditional Chinese medicinal Astragalus membranaceus (Fisch.) Bunge and …

[HTML][HTML] Tyrosol attenuates NASH features by reprogramming the hepatic immune milieu

D Gabbia, K Sayaf, I Zanotto, M Colognesi… - European Journal of …, 2024 - Elsevier
Nonalcoholic steatohepatitis (NASH) is a leading cause of chronic liver disease, and no
drugs have been approved for its therapy. Among plant-derived molecules, phenolic …

The Immune-Stimulating and Anti-Diabetic Effects of Allium hookeri Leaves Grown in a Plant Factory with Artificial Lights in Immunosuppressed Obese C57BL/6 Mice

J Jung, JS Kim, UY Jeong, UJ Bae, M Kim, SY Park… - Pharmaceuticals, 2024 - mdpi.com
We investigated the immune-stimulating and anti-diabetic effects of Allium hookeri leaves
grown in a plant factory with artificial lights. The immunomodulatory effects of A. hookeri …

Endogenous blocking of TLR2 along with TNF-α and IL-1β ameliorates the severity of the S. aureus arthritis via modulating STAT3/SOCS3 expressions in tissue …

R Ghosh, B Bishayi - Microbial Pathogenesis, 2024 - Elsevier
In vivo studies identifying a role of TLR2 in septic arthritis models are lacking. TNF-α played
as the most important proinflammatory cytokine, and connected directly to the pathogenesis …

Computational analysis followed by in vitro studies to explore cytokines (TNF‐α, IL‐6 and IL‐1β) inhibition potential of the new natural molecule polonilignan

PP Pal, PS Lakshmi Soukya, S Gupta… - Chemical Biology & …, 2024 - Wiley Online Library
Targeting pro‐inflammatory cytokines and their production is found to be of therapeutic
benefit for the regulation of inflammation in various chronic autoimmune diseases. Our …

Molecular networking-guided isolation strategy of a new C-glycosyl flavone rotamer from Stellaria alsine and evaluation of anti-inflammatory and antioxidant …

CK Kim, S Yu, M Lee - Metabolomics, 2023 - Springer
Introduction Stellaria alsine has traditionally been used as both a famine relief food and an
alternative medicine in East Asia. Modern pharmacological studies have revealed that S …

基于多种化疗肠损伤发生机制的中医药防治进展

李爽, 韩淑贞, 戴瑜婷, 修明慧… - 中国临床药理学 …, 2023 - manu41.magtech.com.cn
肠损伤是临床应用化疗药物的常见不良反应, 限制了化疗药的进一步应用, 并给病人造成严重的
身心负担. 目前化疗肠损伤的发生机制比较复杂, 中医药具有极好的防治作用 …

CLPC1 protein inhibition, antimycobacterial, and anti‐inflammatory properties of the metabolite from Streptomyces wuyuanensis collected in Nghe An province …

HTN Ni, PT Ninh, NT Dung, T Van Chien… - Vietnam Journal of …, 2024 - Wiley Online Library
Streptomyces wuyuanensis A79 was isolated from the soil samples collected in Quynh
Luong mangrove forest, Quynh Luu district, Nghe An province, Vietnam. This strain …