The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions

V Carlini, DM Noonan, E Abdalalem, D Goletti… - Frontiers in …, 2023 - frontiersin.org
Interleukin-10 (IL-10) is a pleiotropic cytokine that has a fundamental role in modulating
inflammation and in maintaining cell homeostasis. It primarily acts as an anti-inflammatory …

Redefining autoimmune disorders' pathoetiology: implications for mood and psychotic disorders' association with neurodegenerative and classical autoimmune …

G Anderson, AF Almulla, RJ Reiter, M Maes - Cells, 2023 - mdpi.com
Although previously restricted to a limited number of medical conditions, there is a growing
appreciation that 'autoimmune'(or immune-mediated) processes are important aspects of a …

[HTML][HTML] Современная концепция аутоиммунитета в ревматологии

ЕЛ Насонов - Научно-практическая ревматология, 2023 - cyberleninka.ru
В спектре механизмов хронического воспаления центральное место занимают два
фундаментальных патологических процесса-аутоиммунитет и аутовоспаление …

Chimeric antigen receptor T cell therapy for autoimmune disease

JB Chung, JN Brudno, D Borie… - Nature Reviews …, 2024 - nature.com
Infusion of T cells engineered to express chimeric antigen receptors (CARs) that target B
cells has proven to be a successful treatment for B cell malignancies. This success inspired …

Association of peripheral B cells and delirium: combined single-cell sequencing and Mendelian randomization analysis

S Tan, S Pan, L Wei, W Chen, B Pan, G Kong… - Frontiers in …, 2024 - frontiersin.org
Background Delirium seriously affects the prognosis of patients and greatly reduces the
ability to work and live. Peripheral inflammatory events may contribute to the development of …

Engineered biological nanoparticles as nanotherapeutics for tumor immunomodulation

JN Rahmat, J Liu, T Chen, ZH Li, Y Zhang - Chemical Society Reviews, 2024 - pubs.rsc.org
Biological nanoparticles, or bionanoparticles, are small molecules manufactured in living
systems with complex production and assembly machinery. The products of the assembly …

Safety and efficacy of C. muridarum vaccines adjuvanted with CpG-1826 and four concentrations of Montanide-ISA-720-VG

A Slepenkin, S Pal, A Rasley, MA Coleman… - npj Vaccines, 2024 - nature.com
It is recommended that the adjuvant Montanide ISA 720 VG be used at a concentration of
70% v/v. At this concentration, Montanide causes at the site of immunization a local …

PLGA-Chitosan Encapsulated IL-10 Nanoparticles Modulate Chlamydia Inflammation in Mice

AN Yilma, R Sahu, P Subbarayan… - International Journal …, 2024 - Taylor & Francis
Introduction Interleukin-10 (IL-10) is a key anti-inflammatory mediator in protecting host from
over-exuberant responses to pathogens and play important roles in wound healing …

Exploring the therapeutic opportunities of potassium channels for the treatment of rheumatoid arthritis

NE More, R Mandlik, S Zine, VS Gawali… - Frontiers in …, 2024 - frontiersin.org
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that affects the
synovial joint, which leads to inflammation, loss of function, joint destruction, and disability …

[HTML][HTML] Mapping cellular interactions from spatially resolved transcriptomics data

J Zhu, Y Wang, WY Chang, A Malewska, F Napolitano… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Cell-cell communication (CCC) is essential to how life forms and functions. However,
accurate, high-throughput mapping of how expression of all genes in one cell affects …