ATM in DNA repair in cancer
MH Jin, DY Oh - Pharmacology & therapeutics, 2019 - Elsevier
Alterations in DNA damage response (DDR) pathways are hallmarks of cancer. Incorrect
repair of DNA lesions often leads to genomic instability. Ataxia telangiectasia mutated …
repair of DNA lesions often leads to genomic instability. Ataxia telangiectasia mutated …
Kinome screen of ferroptosis reveals a novel role of ATM in regulating iron metabolism
Ferroptosis is a specialized iron-dependent cell death that is associated with lethal lipid
peroxidation. Modulation of ferroptosis may have therapeutic potential since it has been …
peroxidation. Modulation of ferroptosis may have therapeutic potential since it has been …
Glioblastoma: current status, emerging targets, and recent advances
Glioblastoma (GBM) is a highly malignant brain tumor characterized by a heterogeneous
population of genetically unstable and highly infiltrative cells that are resistant to …
population of genetically unstable and highly infiltrative cells that are resistant to …
[HTML][HTML] Re-education of tumor-associated macrophages by CXCR2 blockade drives senescence and tumor inhibition in advanced prostate cancer
D Di Mitri, M Mirenda, J Vasilevska, A Calcinotto… - Cell reports, 2019 - cell.com
Tumor-associated macrophages (TAMs) represent a major component of the tumor
microenvironment supporting tumorigenesis. TAMs re-education has been proposed as a …
microenvironment supporting tumorigenesis. TAMs re-education has been proposed as a …
Combined PARP and ATR inhibition potentiates genome instability and cell death in ATM-deficient cancer cells
RL Lloyd, PWG Wijnhoven, A Ramos-Montoya… - Oncogene, 2020 - nature.com
The poly (ADP-ribose) polymerase (PARP) inhibitor olaparib is FDA approved for the
treatment of BRCA-mutated breast, ovarian and pancreatic cancers. Olaparib inhibits …
treatment of BRCA-mutated breast, ovarian and pancreatic cancers. Olaparib inhibits …
Radioresistance in Glioblastoma and the Development of Radiosensitizers
Simple Summary Numerous mechanisms of glioblastoma (GBM) radioresistance have been
identified but have not yet resulted in development of effective radiosensitizer that can …
identified but have not yet resulted in development of effective radiosensitizer that can …
Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development
Purpose More than 15 years have passed since the first description of the unbound brain-to-
plasma partition coefficient (Kp, uu, brain) by Prof. Margareta Hammarlund-Udenaes, which …
plasma partition coefficient (Kp, uu, brain) by Prof. Margareta Hammarlund-Udenaes, which …
The Hippo pathway effector YAP promotes ferroptosis via the E3 ligase SKP2
Ferroptosis is a new form of regulated cell death resulting from the accumulation of lipid-
reactive oxygen species. A growing number of studies indicate ferroptosis as an important …
reactive oxygen species. A growing number of studies indicate ferroptosis as an important …
Pharmacology of the ATM inhibitor AZD0156: potentiation of irradiation and olaparib responses preclinically
LC Riches, AG Trinidad, G Hughes, GN Jones… - Molecular cancer …, 2020 - AACR
AZD0156 is a potent and selective, bioavailable inhibitor of ataxia-telangiectasia mutated
(ATM) protein, a signaling kinase involved in the DNA damage response. We present …
(ATM) protein, a signaling kinase involved in the DNA damage response. We present …
Targeting DNA repair pathway in cancer: Mechanisms and clinical application
M Wang, S Chen, D Ao - MedComm, 2021 - Wiley Online Library
Over the last decades, the growing understanding on DNA damage response (DDR)
pathways has broadened the therapeutic landscape in oncology. It is becoming increasingly …
pathways has broadened the therapeutic landscape in oncology. It is becoming increasingly …