Radioresistance is the main obstacle in the clinical management of nasopharyngeal
carcinoma (NPC). linc00312 is deregulated in a number of human cancers, including NPC …

Chemo-activation of mitochondrial ClpP exhibits promising anticancer properties. However,
we are currently unaware of any studies using selective and potent ClpP activators in lung …

Glioma is one of the most common and lethal brain tumors. Surgical resection followed by
radiotherapy plus chemotherapy is the current standard of care for patients with glioma. The …

DNA damage response (DDR) is critical to ensure genome stability, and defects in this
signaling pathway are highly associated with carcinogenesis and tumor progression …

Recently, genetically targeted cancer therapies have been a topic of great interest. Synthetic
lethality provides a new approach for the treatment of mutated genes that were previously …

ATRX, a chromatin remodeler protein, is recurrently mutated in H3F3A-mutant pediatric
glioblastoma (GBM) and isocitrate dehydrogenase (IDH)-mutant grade 2/3 adult glioma …

Immune effector cells, including cytotoxic T cells (CTLs), induce apoptosis and eliminate
target cells by direct cell–cell contacts. In vivo, CTLs fail to efficiently kill solid tumor cells by …

Radiotherapy is an important cancer treatment strategy that causes DNA damage in tumor
cells either directly or indirectly. Autophagy is a physiological process linked to DNA …

Steroid hormone signaling induces vast gene expression programs which necessitate the
local formation of transcription factories at regulatory regions and large-scale alterations of …

Survival in high-risk pediatric neuroblastoma has remained around 50% for the last 20
years, with immunotherapies and targeted therapies having had minimal impact. Here, we …