Genome instability has been identified as one of the enabling hallmarks in cancer. DNA
damage response (DDR) network is responsible for maintenance of genome integrity in …

PARP inhibitors (PARPIs) have revolutionized the treatment of epithelial ovarian cancer, first
for BRCA-associated cancer, and, recently, for all epithelial cancers of serous or high-grade …

Abstract Background Neuroendocrine neoplasms (NENs) represent a heterogeneous class
of rare tumors with increasing incidence. They are characterized by the ability to secrete …

Virtually all glioblastomas treated in the first-line setting will recur in a short period of time,
and the search for alternative effective treatments has so far been unsuccessful. Various …

Background The protein kinase ataxia telangiectasia mutated (ATM) mediates cellular
response to DNA damage induced by radiation. ATM inhibition decreases DNA damage …

The kinase ataxia telangiectasia mutated (ATM) plays a key role in the DNA damage
response (DDR). It is thus essential to visualize spatiotemporal dynamics of ATM activity …

The glycine to cysteine mutation at codon 12 of Kirsten rat sarcoma (KRAS) represents an
Achilles heel that has now rendered this important GTPase druggable. Herein, we report our …

Residual cancer cells that survive drug treatments with targeted therapies act as a reservoir
from which eventual resistant disease emerges. Although there is great interest in …

ATM plays an important role in DNA damage response and is considered a potential target
in cancer therapies. In this study, a goal-directed molecular generation approach based on …

Highlights•Genome sequencing has made personalized therapy the preferred cancer
therapeutic approach.•In the past decade, the relevance of targeting DDR kinases for cancer …