Cholinergic synapses are ubiquitous in the human central nervous system. Their high
density in the thalamus, striatum, limbic system, and neocortex suggest that cholinergic …

Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …

Amyloid-beta (Aß) and hyperphosphorylated tau are hallmark lesions of Alzheimer's disease
(AD). However, the loss of synapses and dysfunctions of neurotransmission are more …

Scientific evidence collected over the past 4 decades suggests that a loss of cholinergic
innervation in the cerebral cortex of patients with Alzheimer's disease is an early pathogenic …

Objective: The dramatic increase in the population with dementia expected in the next
decades is accompanied by the establishment of novel and innovated methods that will offer …

The neurotransmitter acetylcholine (ACh) can regulate neuronal excitability by acting on the
cys-loop cation-conducting ligand-gated nicotinic ACh receptor (nAChR) channels. These …

The basal forebrain cholinergic complex comprising medial septum, horizontal and vertical
diagonal band of Broca, and nucleus basalis of Meynert provides the mayor cholinergic …

This text deals with the same kinds of problems addressed by self-help books and self-
realization programs: anxiety, frustration, loneliness, depression, self-control. However, it …

Alzheimer's disease (AD) is the most common neurodegenerative disorder characterized by
cognitive and intellectual deficits and behavior disturbance. The electroencephalogram …

The cholinergic hypothesis was initially presented over 20 years ago and suggests that a
dysfunction of acetylcholine containing neurons in the brain contributes substantially to the …