Vital internal organs display a left-right (LR) asymmetric arrangement that is established
during embryonic development. Disruption of this LR asymmetry—or laterality—can result in …

Homeobox genes encode sequence-specific transcription factors (SSTFs) that recognize
specific DNA sequences and regulate organogenesis in all eukaryotes. They are essential …

The ultimate formation of a four-chambered heart allowing the separation of the pulmonary
and systemic circuits was key for the evolutionary success of tetrapods. Complex processes …

Cardiovascular development is a complex developmental process starting with the formation
of an early straight heart tube, followed by a rightward looping and the configuration of atrial …

Cardiovascular development is initiated soon after gastrulation as bilateral precardiac
mesoderm is progressively symmetrically determined at both sides of the developing …

Cardiovascular development is governed by a complex interplay between inducting signals
such as Bmps and Fgfs leading to activation of cardiac specific transcription factors such as …

Pediatric cardiologists treating patients with severe congenital cardiac defects define
“visceral heterotaxy” on the basis of isomerism of the atrial appendages. The isomeric …

Human beings are characterized by a left–right asymmetric arrangement of their internal
organs, and the heart is the first organ to break symmetry in the developing embryo …

There is growing evidence that putative gene regulatory networks including cardio-enriched
transcription factors, such as PITX2, TBX5, ZFHX3, and SHOX2, and their effector/target …

Cardiovascular development is a complex process that starts with the formation of
symmetrically located precardiac mesodermal precursors soon after gastrulation and is …