The present work aims to examine the worrying problem of antibiotic resistance and the
emergence of multidrug-resistant bacterial strains, which have now become really common …

Antibacterial resistance is one of the greatest threats to human health. The development of
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …

Background New antibiotics are needed for the treatment of patients with life-threatening
carbapenem-resistant Gram-negative infections. We assessed the efficacy and safety of …

Cefiderocol appears promising, as it can overcome most β-lactam resistance mechanisms
(including β-lactamases, porin mutations, and efflux pumps). Resistance is uncommon …

There is an urgent global need for new strategies and drugs to control and treat multidrug-
resistant bacterial infections. In 2017, the World Health Organization (WHO) released a list of …

Antibiotics changed medical practice by significantly decreasing the morbidity and mortality
associated with bacterial infection. However, infectious diseases remain the leading cause …

Infections due to multidrug-resistant Enterobacteriaceae have become major international
public health problem due to the inadequate treatment options and the historically lagged …

Introduction Sulfur-containing functional groups are privileged motifs that occur in various
pharmacologically effective substances and several natural products. Various functionalities …

Antimicrobial resistance has become one of the greatest threats to public health, with rising
resistance to carbapenems being a particular concern due to the lack of effective and safe …

Carbapenem-resistant gram-negative bacteria including Enterobacteriaceae as well as
nonfermenters, such as Pseudomonas aeruginosa and Acinetobacter baumannii, have …