As a leading cause of death, second only to heart disease, cancer has always been one of
the burning topics in medical research. When targeting multiple signal pathways in …

The molecular determinants of the heterogenic course of prostate cancer (PC) remain
elusive. We aimed to determine the drivers predisposing to unfavorable PC outcomes …

Motivation As a highly heterogeneous disease, clear cell renal cell carcinoma (ccRCC) has
quite variable clinical behaviors. The prognostic biomarkers play a crucial role in stratifying …

Objectives: PD-1 and PD-L1 overexpression in malignant tumors in response to
radiotherapy is correlated with a poor prognosis. Human papilloma virus (HPV) infection …

Our study is to explore the expression profiles and potential functions of circRNAs in prostate
cancer (PCa). A total of 95 circRNAs and 830 mRNAs were screened to be significantly …

This study examined whether differential DNA methylation is associated with clinical
features of more aggressive disease at diagnosis and prostate cancer recurrence in African …

Abstract Phosphoribosyl pyrophosphate synthetases 2 (PRPS2) protein function as
nucleotide synthesis enzyme that plays vital roles in cancer biology. However, the …

Background Identifying the subset of patients with clinically localized prostate cancer (PCa)
at the highest risk of recurrence remains challenging, and better prognostic markers are …

Prostate cancer (PC) remains a worldwide challenge, as does the question of how to
distinguish its indolent from its aggressive form to reconcile proper management of the …

Background ETS-related gene (ERG) oncogenic activation is the most common genomic
alteration in prostate cancer (CaP) although it occurs less frequently in African American …