Blood-Brain Barrier (BBB) disruption is an important pathophysiological process of acute
ischemic stroke (AIS), resulting in devastating malignant brain edema and hemorrhagic …

Stroke, including ischemic stroke and hemorrhagic stroke can cause massive neuronal
death and disruption of brain structure, which is followed by secondary inflammatory injury …

In acute ischemic stroke therapy, potent neuroprotective agents are needed that prevent
neural injuries caused by reactive oxygen species (ROS) during ischemic reperfusion …

Statins are a class of widely prescribed drugs used to reduce low-density lipoprotein
cholesterol (LDL-C) and important to prevent cardiovascular diseases (CVD). Most statin …

Ischemic stroke (IS) is a cerebrovascular disease causing high rates of disability and fatality.
In recent years, the concept of the neurovascular unit (NVU) has been accepted by an …

Introduction: Statins are effective in preventing vascular disease and are widely
recommended and used for the secondary prevention of ischemic stroke. However, there is …

Ischemic stroke (IS) causes severe disability and high mortality worldwide. Stem cell (SC)
therapy exhibits unique therapeutic potential for IS that differs from current treatments. SC's …

Background Microglia-mediated neuroinflammation is the major contributor to the secondary
brain injury of ischemic stroke. NLRP3 is one of the major components of ischemia-induced …

Astrocytes have key regulatory roles in central nervous system (CNS), integrating metabolic,
inflammatory and synaptic responses. In this regard, type I interferon (IFN) receptor signaling …

Ischemic stroke is the leading cause of death and long-term disability worldwide, and, while
considerable progress has been made in understanding its pathophysiology, the lack of …