An underlying hallmark of cancers is their genomic instability, which is associated with a
greater propensity to accumulate DNA damage. Historical treatment of cancer by …

Radiobiological modelling has been a key part of radiation biology and therapy for many
decades, and many aspects of clinical practice are guided by tools such as the linear …

Radiotherapy remains an important treatment modality in nearly two thirds of all cancers,
including the primary curative or palliative treatment of breast cancer. Unfortunately, largely …

Purpose: Predominant causes of head and neck cancer recurrence after radiotherapy are
rapid repopulation, hypoxia, fraction of cancer stem cells, and intrinsic radioresistance …

Variations in the intrinsic radiosensitivity of different cells to ionizing radiation is now widely
believed to be a significant driver in differences in response to radiotherapy. While the …

Background Genetically engineered mouse models (GEMMs) of cancer are powerful tools to
study mechanisms of disease progression and therapy response, yet little is known about …

Predicting the responses of biological systems to ionising radiation is extremely challenging,
particularly when comparing X-rays and heavy charged particles, due to the uncertainty in …

Abstract Microsomal glutathione transferase 1 (MGST1) is a member of the MAPEG family
(membrane associated proteins in eicosanoid and glutathione metabolism), defined …

A 31-gene signature derived by integrating four different microarray experiments, has been
found to have a potential for predicting radiosensitivity of cancer cells, but it was seldom …

Cancer is the leading cause of mortality among men and women worldwide. Despite the
availability of numerous diagnostic techniques for various cancers, the overall survival rate …