Interaction between drugs and the gut microbiome

RK Weersma, A Zhernakova, J Fu - Gut, 2020 - gut.bmj.com
The human gut microbiome is a complex ecosystem that can mediate the interaction of the
human host with their environment. The interaction between gut microbes and commonly …

[HTML][HTML] The association between early-life gut microbiota and long-term health and diseases

A Sarkar, JY Yoo, S Valeria Ozorio Dutra… - Journal of clinical …, 2021 - mdpi.com
Early life gut microbiota have been increasingly recognized as major contributors to short
and/or long-term human health and diseases. Numerous studies have demonstrated that …

[HTML][HTML] Influence of the microbiome, diet and genetics on inter-individual variation in the human plasma metabolome

L Chen, DV Zhernakova, A Kurilshikov… - Nature medicine, 2022 - nature.com
The levels of the thousands of metabolites in the human plasma metabolome are strongly
influenced by an individual's genetics and the composition of their diet and gut microbiome …

The gut microbiome modulates the protective association between a Mediterranean diet and cardiometabolic disease risk

DD Wang, LH Nguyen, Y Li, Y Yan, W Ma, E Rinott… - Nature medicine, 2021 - nature.com
To address how the microbiome might modify the interaction between diet and
cardiometabolic health, we analyzed longitudinal microbiome data from 307 male …

Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals

F Asnicar, SE Berry, AM Valdes, LH Nguyen… - Nature medicine, 2021 - nature.com
The gut microbiome is shaped by diet and influences host metabolism; however, these links
are complex and can be unique to each individual. We performed deep metagenomic …

Association of insulin resistance and type 2 diabetes with gut microbial diversity: a microbiome-wide analysis from population studies

Z Chen, D Radjabzadeh, L Chen… - JAMA network …, 2021 - jamanetwork.com
Importance Previous studies have indicated that gut microbiome may be associated with
development of type 2 diabetes. However, these studies are limited by small sample size …

[HTML][HTML] An online atlas of human plasma metabolite signatures of gut microbiome composition

KF Dekkers, S Sayols-Baixeras, G Baldanzi… - Nature …, 2022 - nature.com
Human gut microbiota produce a variety of molecules, some of which enter the bloodstream
and impact health. Conversely, dietary or pharmacological compounds may affect the …

[HTML][HTML] The long-term genetic stability and individual specificity of the human gut microbiome

L Chen, D Wang, S Garmaeva, A Kurilshikov, AV Vila… - Cell, 2021 - cell.com
By following up the gut microbiome, 51 human phenotypes and plasma levels of 1,183
metabolites in 338 individuals after 4 years, we characterize microbial stability and variation …

[HTML][HTML] Microbiome and metabolome features of the cardiometabolic disease spectrum

S Fromentin, SK Forslund, K Chechi… - Nature medicine, 2022 - nature.com
Previous microbiome and metabolome analyses exploring non-communicable diseases
have paid scant attention to major confounders of study outcomes, such as common, pre …

[HTML][HTML] The gut microbiota-bile acid axis links the positive association between chronic insomnia and cardiometabolic diseases

Z Jiang, L Zhuo, Y He, Y Fu, L Shen, F Xu… - Nature …, 2022 - nature.com
Evidence from human cohorts indicates that chronic insomnia is associated with higher risk
of cardiometabolic diseases (CMD), yet whether gut microbiota plays a role is unclear. Here …