Tumors cannot be understood in isolation from their microenvironment. Tumor and stromal
cells change phenotype based upon biochemical and biophysical inputs from their …

The tumor microenvironment (TME) presents a challenging barrier for effective nanotherapy-
mediated drug delivery to solid tumors. In particular for tumors less vascularized than the …

The liver plays a key role in the metabolic homeostasis of the whole organism. To carry out
its functions, it is endowed with a peculiar circulatory system, made of three main dendritic …

Colorectal cancer and other cancers often metastasize to the liver in later stages of the
disease, contributing significantly to patient death. While the biomechanical properties of the …

We describe a multi-scale, liver-centric in silico modeling framework for acetaminophen
pharmacology and metabolism. We focus on a computational model to characterize whole …

Computational models of normal liver function and xenobiotic induced liver damage are
increasingly being used to interpret in vitro and in vivo data and as an approach to the de …

Background and objective Blood flow rate and pressure can be measured in vivo by
invasive and non-invasive techniques in the large vessels of the hepatic vasculature, but it is …

A comprehensive overview of the latest achievements, trends, and the current state of the art
of this important and rapidly expanding field. Clearly and logically structured, the first part of …

Blood flow inside the liver plays a key role in hepatic functions, and abnormal
hemodynamics are highly correlated with liver diseases. To date, the flow field in an …

There is a great deal of demand for the construction of transplantable liver grafts. Over the
last decade, decellularization techniques have been developed to construct whole liver …