Since 1984, when paclitaxel was approved by the FDA for the treatment of advanced
ovarian carcinoma, taxanes have been widely used as microtubule-targeting antitumor …

Microtubules are dynamic filamentous cytoskeletal proteins composed of tubulin and are an
important therapeutic target in tumour cells. Agents that bind to microtubules have been part …

Microtubules are dynamic structures composed of α–β-tubulin heterodimers that are
essential in cell division and are important targets for cancer drugs. Mutations in β-tubulin …

Bladder cancer (BC) is the 11th most common diagnosed cancer, and a number of factors
including environmental and genetic ones participate in BC development. Metastasis of BC …

Autophagy is an evolutionarily conserved mechanism of cellular self‐digestion in which
proteins and organelles are degraded through delivery to lysosomes. Defects in this process …

Recent research has indicated a new mode of intercellular communication facilitated by the
movement of RNA between cells. There is evidence that RNA can transfer between cells in a …

Aberrant expression of microRNAs has been recently associated with chronic lymphocytic
leukemia (CLL) outcome. Although disease evolution can be predicted by several …

Since its discovery in 1998, RNA interference (RNAi) has revolutionized basic and clinical
research. Small RNAs, including small interfering RNA (siRNA), short hairpin RNA (shRNA) …

Mutant p53 proteins are expressed at high frequency in human tumors and are associated
with poor clinical prognosis and resistance to chemotherapeutic treatments. Here we show …

Macroautophagy (hereafter referred to as autophagy) is an evolutionarily conserved self-
degradative process, which involves the regular turnover of cellular components via …