Bile acids are soluble derivatives of cholesterol produced in the liver that subsequently
undergo bacterial transformation yielding a diverse array of metabolites. The bulk of bile …

Cancer is one of the primary causes of death worldwide, and its incidence continues to
increase yearly. Despite significant advances in research, the search for effective and …

Liver X receptors α and β (LXRα and LXRβ) are nuclear receptors with pivotal roles in the
transcriptional control of lipid metabolism. Transcriptional activity of LXRs is induced in …

Distinct macrophage populations throughout the body display highly heterogeneous
transcriptional and epigenetic programs. Recent research has highlighted that these profiles …

Efficient inflammation resolution is important not only for the termination of the inflammatory
response but also for the restoration of tissue integrity. An integral process to resolution of …

Tissue-resident macrophages are present in most tissues with developmental, self-renewal,
or functional attributes that do not easily fit into a textbook picture of a plastic and …

The liver X receptors (LXRs) are pivotal regulators of lipid homeostasis in mammals. These
transcription factors control the expression of a battery of genes involved in the uptake …

Adaptive immunity is essential for pathogen and tumor eradication, but may also trigger
uncontrolled or pathological inflammation. T cell receptor, co-stimulatory and cytokine …

The liver is the central metabolic hub which coordinates nutritional inputs and metabolic
outputs. Food intake releases bile acids which can be sensed by the bile acid receptor FXR …

Small-molecule inhibitors targeting growth factor receptors have failed to show efficacy for
brain cancers, potentially due to their inability to achieve sufficient drug levels in the CNS …