Excessive daytime sleepiness (EDS) is a public health issue. However, it remains largely
undervalued, scarcely diagnosed, and poorly supported. Variations in the definition of EDS …

Abstract Narcolepsy type 1 (NT1) is a chronic sleep disorder resulting from the loss of a
small population of hypothalamic neurons that produce wake-promoting hypocretin (HCRT; …

Background Narcolepsy type 1 is caused by severe loss or lack of brain orexin
neuropeptides. Methods We conducted a phase 2, randomized, placebo-controlled trial of …

Antibiotics are recognised as, on occasion, producing psychiatric side effects, most notably
depression and anxiety. Apart from antimicrobial activity, antibiotics have multiple off‐target …

Introduction: This guideline establishes clinical practice recommendations for the treatment
of central disorders of hypersomnolence in adults and children. Methods: The American …

Idiopathic hypersomnia is a central hypersomnolence disorder of unknown origin
characterized by excessive daytime sleepiness despite normal or long sleep time, and …

Abstract Study Objectives To assess the efficacy and safety of FT218, a novel once-nightly
formulation of sodium oxybate (ON-SXB), in patients with narcolepsy in the phase 3 REST …

Efficacious stem cell-based therapies for traumatic brain injury (TBI) depend on successful
delivery, migration, and engraftment of stem cells to induce neuroprotection. L-myc …

Purpose Narcolepsy is a rare debilitating disorder for which multiple novel pharmacological
options have been approved as treatment for the past few years. The current study …

Background Idiopathic hypersomnia is a central hypersomnolence disorder mainly
characterised by excessive daytime sleepiness, with prolonged night-time sleep and …