Radiometals for combined imaging and therapy

CS Cutler, HM Hennkens, N Sisay… - Chemical …, 2013 - ACS Publications
The use of radionuclides in medicine is based largely on the discoveries of two critical
concepts, the “tracer principle” and the “magic bullet”. In 1913, George de Hevesy …

Antibody tumor penetration: transport opposed by systemic and antigen-mediated clearance

GM Thurber, MM Schmidt, KD Wittrup - Advanced drug delivery reviews, 2008 - Elsevier
Antibodies have proven to be effective agents in cancer imaging and therapy. One of the
major challenges still facing the field is the heterogeneous distribution of these agents in …

Antibody-targeted radiation cancer therapy

DE Milenic, ED Brady, MW Brechbiel - Nature Reviews Drug Discovery, 2004 - nature.com
Several monoclonal antibodies are now approved for cancer therapy, such as rituximab, an
anti-CD20 monoclonal antibody for the treatment of B-cell non-Hodgkin's lymphoma …

The promise of targeted α-particle therapy

DA Mulford, DA Scheinberg… - Journal of Nuclear …, 2005 - Soc Nuclear Med
The use of monoclonal antibodies to deliver radioisotopes directly to tumor cells has
become a promising strategy to enhance the antitumor effects of native antibodies. Since the …

Cancer radioimmunotherapy with alpha-emitting nuclides

O Couturier, S Supiot, M Degraef-Mougin… - European journal of …, 2005 - Springer
In lymphoid malignancies and in certain solid cancers such as medullary thyroid carcinoma,
somewhat mixed success has been achieved when applying radioimmunotherapy (RIT) with …

Targeted α-therapy: past, present, future?

MW Brechbiel - Dalton Transactions, 2007 - pubs.rsc.org
Monoclonal antibodies have become a viable strategy for the delivery of therapeutic, particle
emitting radionuclides specifically to tumor cells to either augment anti-tumor action of the …

Recent progress of astatine-211 in endoradiotherapy: Great advances from fundamental properties to targeted radiopharmaceuticals

F Li, Y Yang, J Liao, N Liu - Chinese Chemical Letters, 2022 - Elsevier
Abstract Astatine-211 (211 At, t 1/2= 7.21 h) emitting two α particles with energies of 5.87
and 7.45 MeV, can lead to a high linear energy transfer (LET= 98.84 keV/µm) and short …

Applications of heteronuclear NMR spectroscopy in biological and medicinal inorganic chemistry

L Ronconi, PJ Sadler - Coordination Chemistry Reviews, 2008 - Elsevier
There is a wide range of potential applications of inorganic compounds, and metal
coordination complexes in particular, in medicine but progress is hampered by a lack of …

Tumour therapy with radionuclides: assessment of progress and problems

J Carlsson, EF Aronsson, SO Hietala… - Radiotherapy and …, 2003 - Elsevier
Radionuclide therapy is a promising modality for treatment of tumours of haematopoietic
origin while the success for treatment of solid tumours so far has been limited. The authors …

Efforts to Control the Errant Products of a Targeted In vivo Generator

J Singh Jaggi, BJ Kappel, MR McDevitt, G Sgouros… - Cancer research, 2005 - AACR
Alpha-particle immunotherapy by targeted α-emitters or α-emitting isotope generators is a
novel form of extraordinarily potent cancer therapy. A major impediment to the clinical use of …