The central nervous system (CNS) encompasses the brain and spinal cord and is
considered the processing center and the most vital part of human body. The central …

The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB) separate
the brain and cerebrospinal fluid (CSF) from the systemic circulation and represent a barrier …

Abstract Background SARS-CoV-2, a coronavirus (CoV), is known to cause acute respiratory
distress syndrome, and a number of non-respiratory complications, particularly in older male …

Alzheimer's disease (AD) is the most prevalent type of dementia, characterized by the
presence of amyloid‐β (Aβ) plaques. We previously reported that Klotho lowered Aβ levels …

Background As a consequence of SARS-CoV-2 infection various neurocognitive and
neuropsychiatric symptoms can appear, which may persist for several months post infection …

Zika virus (ZIKV) can infect and cause microcephaly and Zika-associated neurological
complications in the developing fetal and adult brains. In terms of pathogenesis, a critical …

Background The brain barriers establish compartments in the central nervous system (CNS)
that significantly differ in their communication with the peripheral immune system. In this …

The role of B cells in multiple sclerosis (MS) is increasingly recognized. B cells undergo
compartmentalized redistribution in blood and cerebrospinal fluid (CSF) during active MS …

Effective and timely delivery of therapeutic agents from the systemic circulation to the central
nervous system (CNS) is often precluded by the blood–brain barrier (BBB) and the blood …

The pharmaceutical research sector has been facing the challenge of neurotherapeutics
development and its inherited high-risk and high-failure-rate nature for decades. This hurdle …