Endogenous retroviruses (ERVs), deriving from exogenous retroviral infections of germ line
cells occurred millions of years ago, represent~ 8% of human genome. Most ERVs are …

There are∼ 4500 genes within the 'druggable genome', the subset of the human genome
that expresses proteins able to bind drug-like molecules, yet existing drugs only target a few …

Histone chaperones and chromatin remodelers control nucleosome dynamics, which are
essential for transcription, replication, and DNA repair. The histone chaperone Anti …

Environmental agents like ionizing radiation (IR) and chemotherapeutic drugs can cause
severe damage to the DNA, often in the form of double-strand breaks (DSBs). Remaining …

Three‐gated reconfigurable field‐effect transistors are innovative nanoelectronic devices
that are rapidly and increasingly attracting substantial interest in several fields of application …

Research question What are the molecular mechanisms leading to human sperm DNA
damage? Design Semen samples were collected and the sperm DNA fragmentation index …

Background: Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous sarcoma
characterized by local invasion and recurrence. RNA sequencing (RNA-seq) allows the …

Background: Tousled-like kinase 2 (TLK2) is integral to DNA repair, replication, and cell
cycle regulation, crucial for maintaining genome stability and integrity. However, the …

Tropical calcific pancreatitis (TCP) is a juvenile form of non-alcoholic chronic pancreatitis
seen exclusively in tropical countries. The disease poses a high risk of complications …

Background The Tousled-like kinases 1 and 2 (TLK1/TLK2) regulate DNA replication, repair
and chromatin maintenance. TLK2 variants are associated with 'Intellectual Disability …