Tryptophan in health and disease
S Comai, A Bertazzo, M Brughera, S Crotti - Advances in clinical chemistry, 2020 - Elsevier
Tryptophan (TRP), an essential amino acid in mammals, is involved in several physiological
processes including neuronal function, immunity, and gut homeostasis. In humans, TRP is …
processes including neuronal function, immunity, and gut homeostasis. In humans, TRP is …
Kynurenines in CNS disease: regulation by inflammatory cytokines
BM Campbell, E Charych, AW Lee… - Frontiers in neuroscience, 2014 - frontiersin.org
The kynurenine pathway (KP) metabolizes the essential amino acid tryptophan and
generates a number of neuroactive metabolites collectively called the kynurenines …
generates a number of neuroactive metabolites collectively called the kynurenines …
Effect of immune activation on the kynurenine pathway and depression symptoms–a systematic review and meta-analysis
Dysregulated kynurenine (KYN) pathway has been implicated in the pathophysiology of
depression. In this systematic review, we examined the relationship between kynurenine …
depression. In this systematic review, we examined the relationship between kynurenine …
The role of tryptophan metabolites in neuropsychiatric disorders
In recent decades, neuropsychiatric disorders such as major depressive disorder,
schizophrenia, bipolar, etc., have become a global health concern, causing various …
schizophrenia, bipolar, etc., have become a global health concern, causing various …
L-Tryptophan-kynurenine pathway enzymes are therapeutic target for neuropsychiatric diseases: Focus on cell type differences
H Fujigaki, Y Yamamoto, K Saito - Neuropharmacology, 2017 - Elsevier
The kynurenine pathway (KP) is the major route for tryptophan (TRP) metabolism in most
mammalian tissues. The KP metabolizes TRP into a number of neuroactive metabolites …
mammalian tissues. The KP metabolizes TRP into a number of neuroactive metabolites …
Monoamine oxidase A gene promoter methylation and transcriptional downregulation in an offender population with antisocial personality disorder
D Checknita, G Maussion, B Labonté… - The British Journal of …, 2015 - cambridge.org
BackgroundAntisocial personality disorder (ASPD) is characterised by elevated impulsive
aggression and increased risk for criminal behaviour and incarceration. Deficient activity of …
aggression and increased risk for criminal behaviour and incarceration. Deficient activity of …
Reduced peripheral availability of tryptophan and increased activation of the kynurenine pathway and cortisol correlate with major depression and suicide
A Messaoud, R Mensi, W Douki, F Neffati… - The World Journal of …, 2019 - Taylor & Francis
Objectives: Patients affected by major depression (MDD) are at high risk of suicide. The
metabolism of tryptophan (Trp) along the serotonin (5-HT) and kynurenine (Kyn) pathways …
metabolism of tryptophan (Trp) along the serotonin (5-HT) and kynurenine (Kyn) pathways …
Tryptophan catabolism in chronic viral infections: handling uninvited guests
L-Tryptophan (L-Trp) is an essential amino acid that possesses diverse metabolic,
neurological, and immunological roles spanning from the synthesis of proteins …
neurological, and immunological roles spanning from the synthesis of proteins …
Central nervous system myeloid cells as drug targets: current status and translational challenges
Myeloid cells of the central nervous system (CNS), which include parenchymal microglia,
macrophages at CNS interfaces and monocytes recruited from the circulation during …
macrophages at CNS interfaces and monocytes recruited from the circulation during …
Liver-brain inflammation axis
C D'Mello, MG Swain - American Journal of Physiology …, 2011 - journals.physiology.org
It is becoming increasingly evident that peripheral organ-centered inflammatory diseases,
including chronic inflammatory liver diseases, are associated with changes in central neural …
including chronic inflammatory liver diseases, are associated with changes in central neural …