Senescence is a cellular response to a variety of stress signals that is characterized by a
stable withdrawal from the cell cycle and major changes in cell morphology and physiology …

Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Cellular senescence plays a critical role in tumorigenesis. Once thought of as a tissue
culture artefact by some researchers, senescence is now a major field of study. Although …

Cellular senescence is an essential tumor suppressive mechanism that prevents the
propagation of oncogenically activated, genetically unstable, and/or damaged cells …

Liver cancer remains difficult to treat, owing to a paucity of drugs that target critical
dependencies,; broad-spectrum kinase inhibitors such as sorafenib provide only a modest …

KRAS mutant pancreatic ductal adenocarcinoma (PDAC) is characterized by a desmoplastic
response that promotes hypovascularity, immunosuppression, and resistance to chemo-and …

Senescence is a cellular stress response that results in the stable arrest of old, damaged or
pre-neoplastic cells. Oncogene-induced senescence is tumour suppressive but can also …

Cellular senescence is a state comprising an essentially irreversible proliferative arrest
combined with phenotypic changes and pronounced secretory activity. Although …

Cellular senescence is a stable growth arrest that is implicated in tissue ageing and cancer.
Senescent cells are characterized by an upregulation of proinflammatory cytokines, which is …

Compounds with specific cytotoxic activity in senescent cells, or senolytics, support the
causal involvement of senescence in aging and offer therapeutic interventions. Here we …