Over the past few decades, cellular senescence has been identified in cancer patients
undergoing chemotherapy and radiotherapy. Senescent cells are generally characterized by …

A major challenge in treating cancer is posed by intratumor heterogeneity, with different sub-
populations of cancer cells within the same tumor exhibiting therapy resistance through …

Chemotherapy-induced peripheral neuropathy is among the most common dose-limiting
adverse effects of cancer treatment, leading to dose reduction and discontinuation of life …

NK cells are lymphocytes of the innate immune system, which are able to deal promptly with
stressed cells. Cellular senescence is a cell stress response leading to cell cycle arrest that …

Tumor is a representative of cell immortalization, while senescence irreversibly arrests cell
proliferation. Although tumorigenesis and senescence seem contrary to each other, they …

Centrosome aberrations are hallmarks of human cancers and contribute to the senescence
process. Structural and numerical centrosome abnormalities trigger mitotic errors, cellular …

CDK4/6 inhibitors show promising antitumor activity in a variety of solid tumors; however,
their role in head and neck squamous cell carcinoma (HNSCC) requires further …

Background Cure and long-term survival for non-small cell lung cancer (NSCLC) remains
hard to achieve. Cellular senescence, an emerging hallmark of cancer, is considered as an …

Hepatic metastasis is a clinical challenge for colorectal cancer (CRC). Senescent cancer
cells accumulate in CRC favoring tumor dissemination. Whether this mechanism progresses …