Chemotherapy is intended to induce cancer cell death through apoptosis and other
avenues. Unfortunately, as discussed in this article, moderate doses of genotoxic drugs such …

Senescence is a form of irreversible cell cycle arrest. Senescence plays a dual role in
cancer, as both a tumor suppressor by preventing the growth of damaged cells and a cancer …

Senotherapy is an antiageing strategy. It refers to selective killing of senescent cells by
senolytic agents, strengthening the activity of immune cells that eliminate senescent cells or …

Simple Summary Despite tremendous treatment efforts, cancer is still one of the leading
causes of death, with approximately 10 million deaths in 2020. In the last decade …

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in childhood. Recently,
we demonstrated the overexpression of both DNA methyltransferase 3A (DNMT3A) and 3B …

Cellular senescence is a stress response that imposes a growth arrest on cancer and
nonmalignant cells during cancer therapy. By secreting a plethora of proinflammatory factors …

Cellular senescence was first described as a physiological tumor cell suppressor
mechanism that leads to cell growth arrest with production of the senescence-associated …

Thyroid carcinoma (TC) comprises several histotypes with different aggressiveness, from
well (papillary carcinoma, PTC) to less differentiated forms (poorly differentiated and …

As one of the nonessential amino acids (NEAAs), serine is involved in the anabolism of
multiple macromolecular substances by participating in one-carbon unit metabolism. Thus …

Imidazo [1, 2-a] pyridines (IPs) have been studied regarding drug development. The
objective of this work was to evaluate the antileukemic capacity of IP derivatives by …