Transcription dysregulation is a salient characteristic of bladder cancer (BC), but no
appropriate therapeutic target for it has been established. Here, we found that …

Cellular senescence has been listed as a hallmark of cancer, but its role in colorectal cancer
(CRC) remains unclear. We comprehensively evaluated the transcriptome, genome, digital …

The complex mechanisms of ageing biology are increasingly understood. Interventions to
reduce or delay ageing‐associated diseases are emerging. Cancer is one of the diseases …

Cellular senescence constitutes a permanent state of cell cycle arrest in proliferative cells
induced by different stresses. The exploration of tumor pathogenesis and therapies has …

DNA damage response inhibitors (DDRi) may selectively enhance the inactivation of tumor
cells in combination with ionizing radiation (IR). The induction of senescence may be the key …

Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death
and is the most common type of liver cancer. Due to the current paucity of drugs for HCC …

Targeting senescence therapy is a promising anticancer strategy by arresting the cell-cycle
and inducing cellular senescence. However, senescent cells can promote malignancy and …

Highlights•Duocarmycins are powerful cell-killing agents with potential to treat tumours.•The
exceptional potency of the duocarmycins might also be their achilles' heel.•No major …

Glioma is currently the most widespread and malignant primary intracranial tumor, which is
characterized by high heterogeneity and high fatality rates. β-elemene, which is a bioactive …

Cellular senescence—the irreversible cell cycle arrest driven by a variety of mechanisms
and, more specifically, the senescence-associated secretory phenotype (SASP)—is an …