Background: Hepatocellular carcinoma (HCC) is a lethal tumor. Its prognosis prediction
remains a challenge. Meanwhile, cellular senescence, one of the hallmarks of cancer, and …

Excessive amounts of reactive oxygen species (ROS) lead to macromolecular damage and
high levels of cell death with consequent pathological sequelae. We hypothesized that …

The cGAS/STING signaling pathway is an important part of the cytoplasmic DNA sensor,
which can trigger a type I interferon response to microbial infection when pathogenic DNA is …

Background Epigenetic alterations play an important role in hepatocellular carcinoma (HCC)
development. Enhancer of zeste homolog 2 (EZH2) is a well-known epigenetic modifier that …

Senescence is a stress-responsive cellular program that leads to cell cycle arrest. In cancer
cells, senescence has profound implications for tumor aggressiveness and clinical outcome …

Tremendous progress has been achieved in the field of immune checkpoint inhibitors (ICIs)
therapy in lung cancer in recent years. To generate robust, long-lasting anti-tumor immune …

Background Tumor resistance is a frequent cause of therapy failure and remains a major
challenge for the long-term management of colorectal cancer (CRC). The aim of this study …

Long noncoding RNAs (lncRNAs) undergo extensive alternative splicing, but little is known
about isoform functions. A prior investigation of lncRNA RP11-369C8. 1 reported that its …

Introduction Cellular senescence (CS) plays a critical role in cancer development, including
clear cell renal cell carcinoma (ccRCC). Traditional RNA sequencing cannot detect precise …

Senescent cells are found to accumulate in aged individuals, as well as in cancer patients
that receive chemotherapeutic treatment. Although originally believed to halt cancer …