The proton-activated chloride channel (PAC) is active across a wide range of mammalian
cells and is involved in acid-induced cell death and tissue injury,–. PAC has recently been …

Impaired ion channels regulating Golgi pH lead to structural alterations in the Golgi
apparatus, such as fragmentation, which is found, along with cognitive impairment, in …

Mammalian expression systems, particularly the human embryonic kidney (HEK-293) cells,
combined with electrophysiological studies, have greatly benefited our understanding of the …

Efficient clearance of apoptotic cells by phagocytosis, also known as efferocytosis, is
fundamental to developmental biology, organ physiology, and immunology. Macrophages …

During vesicular acidification, chloride (Cl−), as the counterion, provides the electrical shunt
for proton pumping by the vacuolar H+ ATPase. Intracellular CLC transporters mediate Cl …

The sense of taste is an important sentinel governing what should or should not be ingested
by an animal, with high pH sensation playing a critical role in food selection. Here we …

The proton-activated chloride channel ASOR (TMEM206/PAC) permeates anions across
cellular membranes in response to acidification, thereby enhancing acid-induced cell death …

TMEM206 has been recently identified as an evolutionarily conserved chloride channel that
underlies ubiquitously expressed, proton-activated, outwardly rectifying anion currents …

Extracellular proton concentration is at 40 nM when pH is 7.4. In disease conditions such as
brain ischemia, proton concentration can reach µM range. To respond to this increase in …

Microglia are the resident macrophages of the brain. Over the past decade, our
understanding of the function of these cells has significantly improved. Microglia do not only …