Impaired ion channels regulating Golgi pH lead to structural alterations in the Golgi
apparatus, such as fragmentation, which is found, along with cognitive impairment, in …

A transmembrane (TMEM) protein with an unknown function is a type of membrane-
spanning protein expressed in the plasma membrane or the membranes of intracellular …

The mechanoelectrical transduction (MET) channel of cochlear hair cells is gated by the tip
link, but the mechanisms that establish the exquisite force sensitivity of this MET channel are …

Risperidone is routinely used in the clinical management of schizophrenia, but the treatment
response is highly variable among different patients. The genetic underpinnings of the …

The genetic causes of global developmental delay (GDD) and intellectual disability (ID) are
diverse and include variants in numerous ion channels and transporters. Loss-of-function …

Cell volume regulation (CVR) is essential for survival and functions of animal cells. Actually,
normotonic cell shrinkage and swelling are coupled to apoptotic and necrotic cell death and …

Background and Purpose: Brain acidosis is prevalent in stroke and other neurological
diseases. Acidosis can have paradoxical injurious and protective effects. The purpose of this …

Impaired chloride transport affects diverse processes ranging from neuron excitability to
water secretion, which underlie epilepsy and cystic fibrosis, respectively. The ability to image …

Chronic low back pain (LBP) can severely affect daily physical activity. Aberrant osteoclast-
mediated resorption leads to porous endplates for the sensory innervation to cause LBP …

Severe local acidosis causes tissue damage and pain, and is associated with many
diseases, including cerebral and cardiac ischemia, cancer, infection, and inflammation …