Chloride is the most abundant anion in animal cells, and chloride channels allowing its
diffusion across cell membranes have fundamental roles in physiology and diseases …

Extracellular acidification, playing a promoting role in the process of acute pancreatitis, has
been reported to activate Cl− channels in several types of cells. However, whether …

Recently identified proton-activated chloride channel (PAC) contains two transmembrane
helices (S1–S2) and is involved in lysosome function, hypoxia adaption, stroke, and …

Abstract Volume Regulated Anion Channels (VRACs) encoded by the LRRC8 gene family
play critical roles in myriad cellular processes and might represent druggable targets. The …

Chloride channels play important roles in various physiological and pathological functions
by regulating the most abundant free anion ions (Cl−) in all organisms. The molecular …

The utility of CHAPS-PC, a detergent combination for solubilizing membrane proteins, was
investigated as a substitute to digitonin solution for extracting rhodopsin in the measurement …

The pH-sensitive chloride channels (pHCls) are unique chloride channels in invertebrates
and have important roles in regulation of fluid secretion, food selection and intake. pHCls …

Ischemic stroke is a leading cause of death and disability worldwide with limited therapeutic
options. The newly identified proton-activated chloride channel (PAC) has received …

Proton activated chloride (PAC) channels are activated in response to extracellular acidity,
and mediate outwardly rectifying chloride currents. The channels are encoded by the …

Acid-sensing ion channels (ASICs) are trimeric, sodium-selective proton-gated ion channels.
Having ligands as small as protons presents a challenge when studying the structure …