Substantial advances have elucidated some of the central mechanisms underlying the
inflammation, demyelination, and neurodegeneration that occur in multiple sclerosis …

B cells have long played an enigmatic role in the scenario of multiple sclerosis
pathogenesis. This review summarizes recent progress in our understanding of B‐cell …

Objective Our objective was to test whether natalizumab, an antibody against very late
activating antigen (VLA)‐4, interferes with central nervous system immune surveillance as …

We describe a method for correlating the immunoglobulin (Ig) proteomes with the B cell
transcriptomes in human fluid and tissue samples, using multiple sclerosis as a paradigm …

B cells are important in the pathogenesis of multiple sclerosis (MS) and some of the effects
are not dependent on maturation of B cells into immunoglobulin (Ig) producing plasmablasts …

The diagnosis of multiple sclerosis is based on dissemination in time and space. Before
2010 lack of evidence for dissemination in space could be substituted by a paraclinical test …

Antigen presentation is in the center of the immune system, both in host defense against
pathogens, but also when the system is unbalanced and autoimmune diseases like multiple …

Abstract Objective Intrathecal IgG synthesis, persistence of bands of oligoclonal IgG, and
memory B‐cell clonal expansion are well‐characterized features of the humoral response in …

B cells mediate multiple sclerosis (MS) pathogenesis by mechanisms unrelated to
immunoglobulin (Ig). We reported that supernatants (Sup) from cultured B cells from blood of …

Multiple sclerosis (MS) is a severe disease of the central nervous system (CNS)
characterized by autoimmune inflammation and neurodegeneration. Historically, damage to …