Specialized pro-resolving lipid mediators regulate ozone-induced pulmonary and systemic inflammation

B Kilburg-Basnyat, SW Reece, MJ Crouch… - Toxicological …, 2018 - academic.oup.com
Exposure to ozone (O3) induces lung injury, pulmonary inflammation, and alters lipid
metabolism. During tissue inflammation, specialized pro-resolving lipid mediators (SPMs) …

[HTML][HTML] Genetic strain and sex differences in a hyperoxia-induced mouse model of varying severity of bronchopulmonary dysplasia

S Leary, P Das, D Ponnalagu, H Singh… - The American journal of …, 2019 - Elsevier
Bronchopulmonary dysplasia (BPD) is a disease prevalent in preterm babies with a need for
supplemental oxygen, resulting in impaired lung development and dysregulated …

[HTML][HTML] Role of NLRP3 in the exacerbation of ozone-induced allergic rhinitis

X Zhang, N Sun, Y Huang, Y Duan, R Zhang - … and Environmental Safety, 2023 - Elsevier
Objective Allergic rhinitis (AR) is an immunoglobulin E (IgE)-mediated inflammatory disorder
of the nasal mucosa, and the impact of ozone on AR is gaining increasing attention …

The burden of ozone pollution on years of life lost from chronic obstructive pulmonary disease in a city of Yangtze River Delta, China

J Huang, G Li, G Xu, X Qian, Y Zhao, X Pan… - Environmental …, 2018 - Elsevier
Objective Ambient ozone is one of the most important air pollutants with respect to its
impacts on human health and its increasing concentrations globally. However, studies which …

[HTML][HTML] Systemic immunological responses are dependent on sex and ovarian hormone presence following acute inhaled woodsmoke exposure

K Wardhani, S Yazzie, C McVeigh, O Edeh… - Particle and Fibre …, 2024 - Springer
Background Rural regions of the western United States have experienced a noticeable
surge in both the frequency and severity of acute wildfire events, which brings significant …

[HTML][HTML] Comparison of hospitalization and mortality associated with short-term exposure to ambient ozone and PM2. 5 in Canada

HH Shin, P Gogna, A Maquiling, RP Parajuli, L Haque… - Chemosphere, 2021 - Elsevier
Background: Hospitalization and mortality (HM) have been linked to air pollution separately.
However, previous studies have not adequately compared whether air pollution is a stronger …

[HTML][HTML] New insights into the biology and development of lung cancer in never smokers—implications for early detection and treatment

P Wang, S Sun, S Lam, WW Lockwood - Journal of Translational Medicine, 2023 - Springer
Lung cancer is the leading cause of cancer deaths worldwide. Despite never smokers
comprising between 10 and 25% of all cases, lung cancer in never smokers (LCNS) is …

[HTML][HTML] Vesicular and extravesicular protein analyses from the airspaces of ozone-exposed mice revealed signatures associated with mucoinflammatory lung disease

I Choudhary, T Vo, K Paudel, X Wen, R Gupta… - Scientific reports, 2021 - nature.com
Lung epithelial lining fluid (ELF) harbors a variety of proteins that influence homeostatic and
stress responses in the airspaces. Exosomes, nano-sized extracellular vesicles, contain …

Sex modifies acute ozone-mediated airway physiologic responses

A Birukova, J Cyphert-Daly, RI Cumming… - Toxicological …, 2019 - academic.oup.com
Sex differences clearly exist in incidence, susceptibility, and severity of airway disease and
in pulmonary responses to air pollutants such as ozone (O3). Prior rodent O3 exposure …

Modulation of the lung inflammatory response to ozone by the estrous cycle

N Fuentes, N Cabello, M Nicoleau… - Physiological …, 2019 - Wiley Online Library
Emerging evidence suggests that sex differences exist in the control of lung innate immunity;
however, the specific roles of sex hormones in the inflammatory response, and the …