Oxidative stress has been implicated in the pathogenesis of osteoarthritis and has become
an important therapeutic target. Investigations of various antioxidant supplements, reactive …

As the cellular component of articular cartilage, chondrocytes are responsible for
maintaining in a low-turnover state the unique composition and organization of the matrix …

OBJECTIVE: Age-related changes in multiple components of the musculoskeletal system
may contribute to the well established link between aging and osteoarthritis (OA). This …

Although osteoarthritis (OA) has existed since the dawn of humanity, its pathogenesis
remains poorly understood. OA is no longer considered a “wear and tear” condition but …

Osteoarthritis (OA) is a common debilitating joint disorder, affecting large sections of the
population with significant disability and impaired quality of life. During OA, functional units …

Osteoarthritic cartilage destruction is caused by an imbalance between anabolic and
catabolic factors. Here, we show that hypoxia-inducible factor-2α (HIF-2α, encoded by …

Chondroitin sulfate (CS) being a natural glycosaminoglycan is found in the cartilage and
extracellular matrix. It shows clinical benefits in symptomatic osteoarthritis (OA) of the finger …

Osteoarthritis (OA), primarily characterized by articular cartilage destruction, is the most
common form of age-related degenerative whole-joint disease. No disease-modifying …

Concepts regarding osteoarthritis, the most common joint disease, have dramatically
changed in the past decade thanks to the development of new imaging techniques and the …

Collagen and elastin are the most abundant structural proteins in animals and play an
integral biological and structural role in the extracellular matrix. The biosynthesis and …