Osteoarthritis (OA) has historically been classified as 'primary'where no discernible cause
was evident and 'secondary'where a triggering factor was apparent. Irrespective of the …

Structural disturbances of the subchondral bone are a hallmark of osteoarthritis (OA),
including sclerotic changes, cystic lesions, and osteophyte formation. Osteocytes act as …

We investigated the role of periostin, an extracellular matrix protein, in the pathophysiology
of osteoarthritis (OA). In OA, dysregulated gene expression and phenotypic changes in …

Intraarticular (IA) injections provide the opportunity to deliver biologics directly to their site of
action for a local and efficient treatment of osteoarthritis. However, the synovial joint is a …

Objective. In OA, there is enhanced expression of pro-inflammatory cytokines such as IL-1β
in the affected joint. Delphinidin, an anthocyanidin found in pigmented fruits and vegetables …

Patients with anterior cruciate ligament (ACL) rupture are two times as likely to develop
posttraumatic osteoarthritis (PTOA). Annually, there are∼ 900,000 knee injuries in the …

Abstract Background Codium fragile (Suringar) Hariot has been used as a potential remedy
in traditional medicine because of its anti-inflammatory and anti-oxidant effects …

N-glycan alterations contribute to the progression of several joint diseases, including knee
osteoarthritis (KOA). However, molecular changes in KOA subchondral trabecular bone …

Cartilage tissue is characterized by zonal organization with gradual transitions of
biochemical and mechanical cues from superficial to deep zones. We previously reported …

The most common clinical manifestations of age-related musculoskeletal degeneration are
osteoarthritis and osteoporosis, and these represent an enormous burden on modern …