[HTML][HTML] Elevated levels of TNF-α, IL-1β and IL-6 in the synovial tissue of patients with labral tear: a comparative study with hip osteoarthritis

T Koyama, K Uchida, K Fukushima, Y Ohashi… - BMC Musculoskeletal …, 2021 - Springer
Background Labral tear can be the initiating factor in the onset of hip osteoarthritis (HOA).
However, the physiopathology of labral tear is not fully understood. Our aim was to compare …

Astragaloside inhibits IL-1β-induced inflammatory response in human osteoarthritis chondrocytes and ameliorates the progression of osteoarthritis in mice

H Li, Y Peng, X Wang, X Sun, F Yang… - Immunopharmacology …, 2019 - Taylor & Francis
Background: Osteoarthritis (OA) is a chronic joint-degeneration disease and accounts for the
most frequent arthritis in aging people. OA is characterized by the degeneration of articular …

WNT signaling and cartilage: of mice and men

B Ma, EBM Landman, RL Miclea, JM Wit… - Calcified tissue …, 2013 - Springer
In adult articular cartilage, the extracellular matrix is maintained by a balance between the
degradation and the synthesis of matrix components. Chondrocytes that sparsely reside in …

Nanoenabled Immunomodulatory Scaffolds for Cartilage Tissue Engineering

D Pereira Vasconcelos, C Leite Pereira… - Advanced Functional …, 2024 - Wiley Online Library
Articular cartilage regeneration is a challenge in tissue engineering. Although diverse
materials have been developed for this purpose, cartilage regeneration remains suboptimal …

Coordination-driven self-assembly of metallo-nanodrugs for local inflammation alleviation

L Tang, Z Di, J Zhang, F Yin, L Li, L Zheng - Nano Research, 2023 - Springer
Developing dedicated nanomedicines to improve delivery efficacy of anti-inflammatory
drugs is still a formidable challenge. In this study, we present an extremely simple yet …

Baicalein ameliorates inflammatory-related apoptotic and catabolic phenotypes in human chondrocytes

X Zhang, Y Zhu, X Chen, Y Zhang, Y Zhang… - International …, 2014 - Elsevier
Osteoarthritis (OA), characterized by progressive destruction of articular cartilage, is the most
common form of human arthritis and a major concern for aging societies worldwide. In OA …

[HTML][HTML] The protective effect of ligustilide in osteoarthritis: an in vitro and in vivo study

X Li, D Wu, Z Hu, J Xuan, X Ding, G Zheng… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: Osteoarthritis is a degenerative joint disease characterized by cartilage
degeneration and a chondrocyte inflammatory response that induces an inflammatory …

Berberine inhibits the interleukin‐1 beta‐induced inflammatory response via MAPK downregulation in rat articular chondrocytes

X Li, P He, Y Hou, S Chen, Z Xiao… - Drug development …, 2019 - Wiley Online Library
Osteoarthritis (OA) is one of the most chronic degenerative arthritic diseases, which
gradually results in chondrocyte changes, articular cartilage degeneration, subchondral …

Attenuation of inflammatory events in human intervertebral disc cells with a tumor necrosis factor antagonist

SM Sinclair, MF Shamji, J Chen, L Jing, WJ Richardson… - Spine, 2011 - journals.lww.com
Study Design. The inflammatory responses of primary human intervertebral disc (IVD) cells
to tumor necrosis factor α (TNF-α) and an antagonist were evaluated in vitro. Objective. To …

Localized delivery of curcumin from injectable gelatin/Thai silk fibroin microspheres for anti-inflammatory treatment of osteoarthritis in a rat model

J Ratanavaraporn, K Soontornvipart… - …, 2017 - Springer
The previously developed gelatin/silk fibroin microspheres were loaded with curcumin and
applied for anti-inflammatory treatment in monosodium iodoacetate (MIA)-induced …