T‐cell development in the thymus and activation of mature T cells in secondary lymphoid
organs requires the ability of cells to respond appropriately to environmental signals at …

Harnessing T-cell responses to constrain tumor growth is a realistic treatment aspiration in
tumor medicine, as many tumors express specific tumor associated antigens that are …

The effect of TCR signals on the differentiation of memory T cells is poorly defined.
Conventional wisdom suggests that high-avidity interactions are best for the selection of …

The TS/A cell line was established in 1983 from a spontaneous mammary tumor arisen in an
inbred BALB/c female mouse. Its features (heterogeneity, low immunogenicity and …

An extraordinary variety of potential therapeutic vaccine strategies directed against a wide
variety of tumor antigens has been explored in clinical trials. To date, none of these cancer …

The generation of immunological memory is a hallmark of adaptive immunity by which the
immune system “remembers” a previous encounter with an antigen expressed by …

Chemotherapy has been combined with therapeutic tumor-specific vaccination in an attempt
to simultaneously debulk tumors, increase the effector lymphocyte: tumor cell ratio, and favor …

It is well established that tumours hinder both natural and vaccine‐induced tumour‐specific
CD4+ T‐cell responses. Adoptive T‐cell therapy has the potential to circumvent functional …

CD4+ helper T cells are critical for protective immune responses and yet suboptimally
primed in response to tumors. Cell-based vaccination strategies are under evaluation in …

Purpose To develop a novel cancer vaccine using the targeting system of antigen protein to
antigen-presenting cells (APCs) for efficient and safe cancer therapy. Methods The novel …