Over the past decade, many studies have indicated that adolescence is a critical period of
brain development and maturation. The refinement and maturation of the central nervous …

Adolescence is an important ontogenetic period that is characterized by behaviors such as
enhanced novelty-seeking, impulsivity, and reward preference, which can give rise to an …

Importance Animal studies have shown that the adolescent brain is sensitive to disruptions
in endocannabinoid signaling, resulting in altered neurodevelopment and lasting behavioral …

Objectives The liberalisation of cannabis laws, the increasing availability and potency of
cannabis has renewed concern about the risk of psychosis with cannabis. Methods The …

Background: Cannabis is the most widely used illicit substance worldwide, and legalization
for recreational and medical purposes has substantially increased its availability and use in …

Cannabis is currently the most used illicit substance in the world with a global widespread
distribution. Although its acute neurocognitive effects on human behaviour have been …

The endocannabinoid system is widely expressed in the limbic system, prefrontal cortical
areas, and brain structures regulating neuroendocrine stress responses, which explains the …

Cannabis exposure during the perinatal period results in varied and significant
consequences in affected offspring. The prevalence of detrimental outcomes of perinatal …

Cannabis use peaks in adolescence, and adolescents may be more vulnerable to the neural
effects of cannabis and cannabis-related harms due to ongoing brain development during …

Cannabis use in some individuals can meaningfully introduce de novo risk for the initiation
of opioid use and development of opioid use disorder. These risks may be particularly high …