Objective To determine the independent impact of different definitions of remission and low
disease activity (LDA) on damage accrual. Methods Patients with≥ 2 annual assessments …

Objectives Maintenance of remission has become central in the management of systemic
lupus erythematosus (SLE). The importance of interferon-alpha (IFN-α) in the pathogenesis …

Systemic lupus erythematosus (SLE) is an immune-mediated multi-systemic disease
characterized by a wide variability of clinical manifestations and a course frequently subject …

Objectives There is an unmet need for accurate and user-friendly definitions of systemic
lupus erythematosus (SLE) disease activity and remission. We aimed to derive and validate …

Treat-to-target strategies have changed the approach to management of many chronic
conditions, with improvements in patient outcomes. The key to success of treat to target is …

Background Disease activity in systemic lupus erythematosus follows three different
courses: long quiescent, relapsing remitting and persistently active. However, the patterns of …

Background Remission and low disease activity (LDA) have been proposed as the treatment
goals for patients with systemic lupus erythematosus (SLE). Several definitions for each …

Summary The Physician Global Assessment International Standardisation COnsensus in
Systemic Lupus Erythematosus (PISCOS) study aimed to obtain an evidence-based and …

Objective To achieve a consensus-based definition of Low Disease Activity (LDA) for use in
cSLE trials. Methods The International cSLE T2T Task Force, comprising of paediatric …

Objectives To assess the achievability and effect of attaining low disease activity (LDA) or
remission in childhood-onset SLE (cSLE). Methods Attainment of three adult-SLE derived …