Abnormal accumulation of aggregated α-synuclein (α-Syn) is seen in a variety of
neurodegenerative diseases, including Parkinson's disease (PD), multiple system atrophy …

The accumulation of proteinaceous inclusions in the brain is a common feature among
neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease (PD), and …

Background Isolated rapid-eye-movement (REM) sleep behaviour disorder (IRBD) can be
part of the prodromal stage of the α-synucleinopathies Parkinson's disease and dementia …

Background Multiple system atrophy (MSA) is a neurodegenerative condition characterized
by variable combinations of parkinsonism, autonomic failure, cerebellar ataxia and …

Amyloid aggregation of α-synuclein (αS) is the hallmark of Parkinson's disease and other
synucleinopathies. Recently, Tau protein, generally associated with Alzheimer's disease …

An increasing number of cases where amyloids of different proteins are found in the same
patient are being reported. This observation complicates diagnosis and clinical intervention …

Parkinson disease (PD) is a neurodegenerative disorder characterized by the abnormal
intracellular accumulation of SNCA/α-synuclein. While the exact mechanisms underlying …

Background Assays that specifically measure α‐synuclein seeding activity in biological
fluids could revolutionize the diagnosis of Parkinson's disease. Recent improvements in α …

Many neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease,
are characterised by the accumulation of misfolded protein deposits in the brain, leading to a …

Since the initial identification of alpha-synuclein (α-syn) at the synapse, numerous studies
demonstrated that α-syn is a key player in the etiology of Parkinson's disease (PD) and other …