DNA damage kinase signaling: checkpoint and repair at 30 years
From bacteria to mammalian cells, damaged DNA is sensed and targeted by DNA repair
pathways. In eukaryotes, kinases play a central role in coordinating the DNA damage …
pathways. In eukaryotes, kinases play a central role in coordinating the DNA damage …
The Ku heterodimer: function in DNA repair and beyond
VL Fell, C Schild-Poulter - Mutation Research/Reviews in Mutation …, 2015 - Elsevier
Ku is an abundant, highly conserved DNA binding protein found in both prokaryotes and
eukaryotes that plays essential roles in the maintenance of genome integrity. In eukaryotes …
eukaryotes that plays essential roles in the maintenance of genome integrity. In eukaryotes …
Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity
CDK2 is a core cell-cycle kinase that phosphorylates many substrates to drive progression
through the cell cycle. CDK2 is hyperactivated in multiple cancers and is therefore an …
through the cell cycle. CDK2 is hyperactivated in multiple cancers and is therefore an …
[HTML][HTML] Inhibition of the CDK2 and Cyclin A complex leads to autophagic degradation of CDK2 in cancer cells
Abstract Cyclin-dependent kinase 2 (CDK2) complex is significantly over-activated in many
cancers. While it makes CDK2 an attractive target for cancer therapy, most inhibitors against …
cancers. While it makes CDK2 an attractive target for cancer therapy, most inhibitors against …
[PDF][PDF] CDK substrate phosphorylation and ordering the cell cycle
S phase and mitotic onset are brought about by the action of multiple different cyclin-CDK
complexes. However, it has been suggested that changes in the total level of CDK kinase …
complexes. However, it has been suggested that changes in the total level of CDK kinase …
ATM activation by oxidative stress
The ataxia-telangiectasia mutated (ATM) protein kinase is activated by DNA double-strand
breaks (DSBs) through the Mre11-Rad50-Nbs1 (MRN) DNA repair complex and …
breaks (DSBs) through the Mre11-Rad50-Nbs1 (MRN) DNA repair complex and …
[PDF][PDF] Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2
A major challenge of the post-genomics era is to define the connectivity of protein
phosphorylation networks. Here, we quantitatively delineate the insulin signaling network in …
phosphorylation networks. Here, we quantitatively delineate the insulin signaling network in …
Emerging roles for chromatin as a signal integration and storage platform
AI Badeaux, Y Shi - Nature reviews Molecular cell biology, 2013 - nature.com
Cells of a multicellular organism, all containing nearly identical genetic information, respond
to differentiation cues in variable ways. In addition, cells are plastic, able to execute their …
to differentiation cues in variable ways. In addition, cells are plastic, able to execute their …
Cell cycle, cytoskeleton dynamics and beyond: the many functions of cyclins and CDK inhibitors
N Bendris, B Lemmers, JM Blanchard - Cell cycle, 2015 - Taylor & Francis
While targeting experiments carried out on the genes encoding many cell cycle regulators
have challenged our views of cell cycle control, they also suggest that redundancy might not …
have challenged our views of cell cycle control, they also suggest that redundancy might not …
[PDF][PDF] TRF2 recruits RTEL1 to telomeres in S phase to promote t-loop unwinding
The helicase RTEL1 promotes t-loop unwinding and suppresses telomere fragility to
maintain the integrity of vertebrate telomeres. An interaction between RTEL1 and PCNA is …
maintain the integrity of vertebrate telomeres. An interaction between RTEL1 and PCNA is …