MYC modulation around the CDK2/p27/SKP2 axis
P Hydbring, A Castell, LG Larsson - Genes, 2017 - mdpi.com
MYC is a pleiotropic transcription factor that controls a number of fundamental cellular
processes required for the proliferation and survival of normal and malignant cells, including …
processes required for the proliferation and survival of normal and malignant cells, including …
Post-translational modification localizes MYC to the nuclear pore basket to regulate a subset of target genes involved in cellular responses to environmental signals
The transcription factor MYC (also c-Myc) induces histone modification, chromatin
remodeling, and the release of paused RNA polymerase to broadly regulate transcription …
remodeling, and the release of paused RNA polymerase to broadly regulate transcription …
Proteomic analysis of cell cycle progression in asynchronous cultures, including mitotic subphases, using PRIMMUS
T Ly, A Whigham, R Clarke, AJ Brenes-Murillo, B Estes… - Elife, 2017 - elifesciences.org
The temporal regulation of protein abundance and post-translational modifications is a key
feature of cell division. Recently, we analysed gene expression and protein abundance …
feature of cell division. Recently, we analysed gene expression and protein abundance …
NAADP-binding proteins find their identity
JS Marchant, GS Gunaratne, X Cai, JT Slama… - Trends in biochemical …, 2022 - cell.com
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that
releases Ca 2+ from endosomes and lysosomes by activating ion channels called two-pore …
releases Ca 2+ from endosomes and lysosomes by activating ion channels called two-pore …
Post-translational modifications of the mini-chromosome maintenance proteins in DNA replication
Z Li, X Xu - Genes, 2019 - mdpi.com
The eukaryotic mini-chromosome maintenance (MCM) complex, composed of MCM proteins
2–7, is the core component of the replisome that acts as the DNA replicative helicase to …
2–7, is the core component of the replisome that acts as the DNA replicative helicase to …
Phosphorylation of eukaryotic elongation factor 2 (eEF2) by cyclin A–cyclin-dependent kinase 2 regulates its inhibition by eEF2 kinase
AA Hizli, Y Chi, J Swanger, JH Carter… - … and cellular biology, 2013 - Am Soc Microbiol
Protein synthesis is highly regulated via both initiation and elongation. One mechanism that
inhibits elongation is phosphorylation of eukaryotic elongation factor 2 (eEF2) on threonine …
inhibits elongation is phosphorylation of eukaryotic elongation factor 2 (eEF2) on threonine …
The Ku complex: recent advances and emerging roles outside of non-homologous end-joining
S Abbasi, G Parmar, RD Kelly, N Balasuriya… - Cellular and Molecular …, 2021 - Springer
Since its discovery in 1981, the Ku complex has been extensively studied under multiple
cellular contexts, with most work focusing on Ku in terms of its essential role in non …
cellular contexts, with most work focusing on Ku in terms of its essential role in non …
Phosphosite scanning reveals a complex phosphorylation code underlying CDK-dependent activation of Hcm1
Ordered cell cycle progression is coordinated by cyclin dependent kinases (CDKs). CDKs
often phosphorylate substrates at multiple sites clustered within disordered regions …
often phosphorylate substrates at multiple sites clustered within disordered regions …
γ-Tubulin in microtubule nucleation and beyond
V Sulimenko, E Dráberová, P Dráber - Frontiers in cell and …, 2022 - frontiersin.org
Microtubules composed of αβ-tubulin dimers are dynamic cytoskeletal polymers that play
key roles in essential cellular processes such as cell division, organelle positioning …
key roles in essential cellular processes such as cell division, organelle positioning …
4-Hydroxybenzoic acid (4-HBA) enhances the sensitivity of human breast cancer cells to adriamycin as a specific HDAC6 inhibitor by promoting HIPK2/p53 pathway
XN Wang, KY Wang, XS Zhang, C Yang… - … and biophysical research …, 2018 - Elsevier
Breast cancer is reported a very complex disease along with heterogeneous morphological
characteristics and unrelated clinical behavior, and is a leading cancer among female …
characteristics and unrelated clinical behavior, and is a leading cancer among female …