MYC is a pleiotropic transcription factor that controls a number of fundamental cellular
processes required for the proliferation and survival of normal and malignant cells, including …

The transcription factor MYC (also c-Myc) induces histone modification, chromatin
remodeling, and the release of paused RNA polymerase to broadly regulate transcription …

The temporal regulation of protein abundance and post-translational modifications is a key
feature of cell division. Recently, we analysed gene expression and protein abundance …

Nicotinic acid adenine dinucleotide phosphate (NAADP) is a second messenger that
releases Ca 2+ from endosomes and lysosomes by activating ion channels called two-pore …

The eukaryotic mini-chromosome maintenance (MCM) complex, composed of MCM proteins
2–7, is the core component of the replisome that acts as the DNA replicative helicase to …

Protein synthesis is highly regulated via both initiation and elongation. One mechanism that
inhibits elongation is phosphorylation of eukaryotic elongation factor 2 (eEF2) on threonine …

Since its discovery in 1981, the Ku complex has been extensively studied under multiple
cellular contexts, with most work focusing on Ku in terms of its essential role in non …

Ordered cell cycle progression is coordinated by cyclin dependent kinases (CDKs). CDKs
often phosphorylate substrates at multiple sites clustered within disordered regions …

Microtubules composed of αβ-tubulin dimers are dynamic cytoskeletal polymers that play
key roles in essential cellular processes such as cell division, organelle positioning …

Breast cancer is reported a very complex disease along with heterogeneous morphological
characteristics and unrelated clinical behavior, and is a leading cancer among female …