Sensing Enzymatic Activity by Exposure and Selection of DNA‐Encoded Probes
RR Jetson, CJ Krusemark - Angewandte Chemie International …, 2016 - Wiley Online Library
A sensing approach is applied to encode quantitative enzymatic activity information into
DNA sequence populations. The method utilizes DNA‐linked peptide substrates as activity …
DNA sequence populations. The method utilizes DNA‐linked peptide substrates as activity …
LTA4H regulates cell cycle and skin carcinogenesis
N Oi, H Yamamoto, A Langfald, R Bai, MH Lee… - …, 2017 - academic.oup.com
Abstract Leukotriene A4 hydrolase (LTA4H), a bifunctional zinc metallo-enzyme, is
reportedly overexpressed in several human cancers. Our group has focused on LTA4H as a …
reportedly overexpressed in several human cancers. Our group has focused on LTA4H as a …
CDK2 regulates aminoglycoside-induced hair cell death through modulating c-Jun activity: Inhibiting CDK2 to preserve hearing
L Tao, N Segil - Frontiers in Molecular Neuroscience, 2022 - frontiersin.org
Sensory hair cell death caused by the ototoxic side effects of many clinically used drugs
leads to permanent sensorineural hearing loss in patients. Aminoglycoside antibiotics are …
leads to permanent sensorineural hearing loss in patients. Aminoglycoside antibiotics are …
[HTML][HTML] ERK1/2/MAPK pathway-dependent regulation of the telomeric factor TRF2
Telomere stability is a hallmark of immortalized cells, including cancer cells. While the
telomere length is maintained in most cases by the telomerase, the activity of a protein …
telomere length is maintained in most cases by the telomerase, the activity of a protein …
Molecular architecture of the DNA replication origin activation checkpoint
S Tudzarova, MWB Trotter, A Wollenschlaeger… - The EMBO …, 2010 - embopress.org
Perturbation of DNA replication initiation arrests human cells in G1, pointing towards an
origin activation checkpoint. We used RNAi against Cdc7 kinase to inhibit replication …
origin activation checkpoint. We used RNAi against Cdc7 kinase to inhibit replication …
Cyclin A degradation by primate cytomegalovirus protein pUL21a counters its innate restriction of virus replication
N Caffarelli, AR Fehr, D Yu - PLoS Pathogens, 2013 - journals.plos.org
Cyclin A is critical for cellular DNA synthesis and S phase progression of the cell cycle.
Human cytomegalovirus (HCMV) can reduce cyclin A levels and block cellular DNA …
Human cytomegalovirus (HCMV) can reduce cyclin A levels and block cellular DNA …
Multi‐kinase framework promotes proliferation and invasion of lung adenocarcinoma through activation of dynamin‐related protein 1
KP Chung, YL Huang, YJ Chen, YH Juan… - Molecular …, 2021 - Wiley Online Library
Recent studies revealed the role of dynamin‐related protein 1 (DRP1), encoded by the
DNM1L gene, in regulating the growth of cancer cells of various origins. However, the …
DNM1L gene, in regulating the growth of cancer cells of various origins. However, the …
Cell cycle–dependent regulation and function of ARGONAUTE1 in plants
A Trolet, P Baldrich, MC Criqui, M Dubois… - The Plant …, 2019 - academic.oup.com
Regulated gene expression is key to the orchestrated progression of the cell cycle. Many
genes are expressed at specific points in the cell cycle, including important cell cycle …
genes are expressed at specific points in the cell cycle, including important cell cycle …
Searching for Novel Cdk5 Substrates in Brain by Comparative Phosphoproteomics of Wild Type and Cdk5−/− Mice
E Contreras-Vallejos, E Utreras, DA Bórquez… - PloS one, 2014 - journals.plos.org
Protein phosphorylation is the most common post-translational modification that regulates
several pivotal functions in cells. Cyclin-dependent kinase 5 (Cdk5) is a proline-directed …
several pivotal functions in cells. Cyclin-dependent kinase 5 (Cdk5) is a proline-directed …
Rapamycin‐sensitive mTORC1 signaling is involved in physiological primordial follicle activation in mouse ovary
Y Tong, F Li, Y Lu, Y Cao, J Gao… - Molecular reproduction …, 2013 - Wiley Online Library
In mammals, resting female oocytes reside in primordial ovarian follicles. An individual
primordial follicle may stay quiescent for a protracted period of time before initiating follicular …
primordial follicle may stay quiescent for a protracted period of time before initiating follicular …