A sensing approach is applied to encode quantitative enzymatic activity information into
DNA sequence populations. The method utilizes DNA‐linked peptide substrates as activity …

Abstract Leukotriene A4 hydrolase (LTA4H), a bifunctional zinc metallo-enzyme, is
reportedly overexpressed in several human cancers. Our group has focused on LTA4H as a …

Sensory hair cell death caused by the ototoxic side effects of many clinically used drugs
leads to permanent sensorineural hearing loss in patients. Aminoglycoside antibiotics are …

Telomere stability is a hallmark of immortalized cells, including cancer cells. While the
telomere length is maintained in most cases by the telomerase, the activity of a protein …

Perturbation of DNA replication initiation arrests human cells in G1, pointing towards an
origin activation checkpoint. We used RNAi against Cdc7 kinase to inhibit replication …

Cyclin A is critical for cellular DNA synthesis and S phase progression of the cell cycle.
Human cytomegalovirus (HCMV) can reduce cyclin A levels and block cellular DNA …

Recent studies revealed the role of dynamin‐related protein 1 (DRP1), encoded by the
DNM1L gene, in regulating the growth of cancer cells of various origins. However, the …

Regulated gene expression is key to the orchestrated progression of the cell cycle. Many
genes are expressed at specific points in the cell cycle, including important cell cycle …

Protein phosphorylation is the most common post-translational modification that regulates
several pivotal functions in cells. Cyclin-dependent kinase 5 (Cdk5) is a proline-directed …

In mammals, resting female oocytes reside in primordial ovarian follicles. An individual
primordial follicle may stay quiescent for a protracted period of time before initiating follicular …