The thiamine pyrophosphate (TPP) riboswitch is a cis-regulatory element in mRNA that
modifies gene expression in response to TPP concentration. Its specificity is dependent …

RecA-mediated homologous recombination (HR) is a key mechanism for genome
maintenance and plasticity in bacteria. It proceeds through RecA assembly into a dynamic …

Recent advancements in single-molecule methods have allowed researchers to directly
observe proteins acting on their DNA targets in real-time. Single-molecule imaging of protein …

Magnetic tweezers provide a versatile toolkit supporting the mechanistic investigation of
helicases. In the present article, we show that custom magnetic tweezers setups are …

Helicases are enzymes that move, manage, and manipulate nucleic acids. They can be
subdivided into six super families and are required for all aspects of nucleic acid …

Regions of the genome are often held under torsional constraint. Nevertheless, the influence
of such constraint on DNA–protein interactions during genome metabolism is still poorly …

Superfamily I helicases are nonhexameric helicases responsible for the unwinding of
nucleic acids. However, whether they unwind DNA in the form of monomers or oligomers …

Breast cancer affected 1.7 million people worldwide in 2012 and accounts for approximately
23.3% of all cancers diagnosed in women. The disease is characterized by a genetic …

During meiosis, the two DNA recombinases Rad51 and Dmc1 form specialized presynaptic
filaments that are adapted for performing recombination between homologous …

Helicases are enzymes that convert the chemical energy stored in ATP into mechanical
work, allowing them to move along and manipulate nucleic acids. The helicase superfamily …