The angiotensin AT2 receptor: from a binding site to a novel therapeutic target
UM Steckelings, RE Widdop, ED Sturrock… - Pharmacological …, 2022 - ASPET
Discovered more than 30 years ago, the angiotensin AT2 receptor (AT2R) has evolved from
a binding site with unknown function to a firmly established major effector within the …
a binding site with unknown function to a firmly established major effector within the …
Mechanisms of diabetic complications
It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic
required, but also for its major complications, affecting both small and large blood vessels …
required, but also for its major complications, affecting both small and large blood vessels …
Up-date on diabetic nephropathy
MC Pelle, M Provenzano, M Busutti, CV Porcu, I Zaffina… - Life, 2022 - mdpi.com
Diabetes is one of the leading causes of kidney disease. Diabetic kidney disease (DKD) is a
major cause of end-stage kidney disease (ESKD) worldwide, and it is linked to an increase …
major cause of end-stage kidney disease (ESKD) worldwide, and it is linked to an increase …
The renin–angiotensin–aldosterone system, glucose metabolism and diabetes
In diabetes mellitus (DM), the circulating renin–angiotensin system (RAS) is suppressed, but
the renal tissue RAS is activated. Hyperglycemia increases tissue angiotensin II (Ang II) …
the renal tissue RAS is activated. Hyperglycemia increases tissue angiotensin II (Ang II) …
[HTML][HTML] AT2 receptors in cardiovascular and renal diseases
E Kaschina, P Namsolleck, T Unger - Pharmacological research, 2017 - Elsevier
The renin-angiotensin system (RAS) plays an important role in the initiation and progression
of cardiovascular and renal diseases. These actions mediated by AT1 receptor (AT1R) are …
of cardiovascular and renal diseases. These actions mediated by AT1 receptor (AT1R) are …
AT2 receptors: functional relevance in cardiovascular disease
ES Jones, A Vinh, CA McCarthy, TA Gaspari… - Pharmacology & …, 2008 - Elsevier
The renin angiotensin system (RAS) is intricately involved in normal cardiovascular
homeostasis. Excessive stimulation by the octapeptide angiotensin II contributes to a range …
homeostasis. Excessive stimulation by the octapeptide angiotensin II contributes to a range …
The intrarenal renin–angiotensin system and diabetic nephropathy
The renin–angiotensin system (RAS) is a coordinated cascade of proteins and peptide
hormones, the principal effector of which is angiotensin II (ANG II). Evidence now indicates …
hormones, the principal effector of which is angiotensin II (ANG II). Evidence now indicates …
[HTML][HTML] Role of the renin angiotensin system in diabetic nephropathy
T Chawla, D Sharma, A Singh - World journal of diabetes, 2010 - ncbi.nlm.nih.gov
Diabetic nephropathy has been the cause of lot of morbidity and mortality in the diabetic
population. The renin angiotensin system (RAS) is considered to be involved in most of the …
population. The renin angiotensin system (RAS) is considered to be involved in most of the …
The pathobiology of diabetic vascular complications—cardiovascular and kidney disease
SP Gray, K Jandeleit-Dahm - Journal of molecular medicine, 2014 - Springer
With the increasing incidence of obesity and type 2 diabetes, it is predicted that more than
half of Americans will have diabetes or pre-diabetes by 2020. Diabetic patients develop …
half of Americans will have diabetes or pre-diabetes by 2020. Diabetic patients develop …
Combination therapy with the advanced glycation end product cross-link breaker, alagebrium, and angiotensin converting enzyme inhibitors in diabetes: synergy or …
Blockade of advanced glycation end product (AGE) accumulation with alagebrium with
concomitant angiotensin converting enzyme inhibition was tested for effects on renal …
concomitant angiotensin converting enzyme inhibition was tested for effects on renal …