Discovered more than 30 years ago, the angiotensin AT2 receptor (AT2R) has evolved from
a binding site with unknown function to a firmly established major effector within the …

It is increasingly apparent that not only is a cure for the current worldwide diabetes epidemic
required, but also for its major complications, affecting both small and large blood vessels …

Diabetes is one of the leading causes of kidney disease. Diabetic kidney disease (DKD) is a
major cause of end-stage kidney disease (ESKD) worldwide, and it is linked to an increase …

In diabetes mellitus (DM), the circulating renin–angiotensin system (RAS) is suppressed, but
the renal tissue RAS is activated. Hyperglycemia increases tissue angiotensin II (Ang II) …

The renin-angiotensin system (RAS) plays an important role in the initiation and progression
of cardiovascular and renal diseases. These actions mediated by AT1 receptor (AT1R) are …

The renin angiotensin system (RAS) is intricately involved in normal cardiovascular
homeostasis. Excessive stimulation by the octapeptide angiotensin II contributes to a range …

The renin–angiotensin system (RAS) is a coordinated cascade of proteins and peptide
hormones, the principal effector of which is angiotensin II (ANG II). Evidence now indicates …

Diabetic nephropathy has been the cause of lot of morbidity and mortality in the diabetic
population. The renin angiotensin system (RAS) is considered to be involved in most of the …

With the increasing incidence of obesity and type 2 diabetes, it is predicted that more than
half of Americans will have diabetes or pre-diabetes by 2020. Diabetic patients develop …

Blockade of advanced glycation end product (AGE) accumulation with alagebrium with
concomitant angiotensin converting enzyme inhibition was tested for effects on renal …