The extracellular matrix in skin inflammation and infection

K Pfisterer, LE Shaw, D Symmank… - Frontiers in cell and …, 2021 - frontiersin.org
The extracellular matrix (ECM) is an integral component of all organs and plays a pivotal
role in tissue homeostasis and repair. While the ECM was long thought to mostly have …

Tumor-derived exosomes in the regulation of macrophage polarization

MS Baig, A Roy, S Rajpoot, D Liu, R Savai… - Inflammation …, 2020 - Springer
Background This review focuses on exosomes derived from various cancer cells. The review
discusses the possibility of differentiating macrophages in alternatively activated anti …

Adhesive composite hydrogel patch for sustained transdermal drug delivery to treat atopic dermatitis

YE Kim, HY Jung, N Park, J Kim - Chemistry of Materials, 2023 - ACS Publications
Atopic dermatitis (AD) is a common chronic inflammatory skin disease. Continuous
administration of steroids often causes undesired side effects; hence, drug delivery systems …

Bioinspired and inflammation‐modulatory glycopeptide hydrogels for radiation‐induced chronic skin injury repair

Z Feng, Y Zhang, C Yang, X Liu… - Advanced …, 2023 - Wiley Online Library
Clinical wound management of radiation‐induced skin injury (RSI) remains a great
challenge due to acute injuries induced by excessive reactive oxygen species (ROS), and …

Extracellular matrix stiffness—The central cue for skin fibrosis

K Wang, D Wen, X Xu, R Zhao, F Jiang… - Frontiers in Molecular …, 2023 - frontiersin.org
Skin fibrosis is a physiopathological process featuring the excessive deposition of
extracellular matrix (ECM), which is the main architecture that provides structural support …

Alarmin cytokines as central regulators of cutaneous immunity

T Hasegawa, T Oka, S Demehri - Frontiers in Immunology, 2022 - frontiersin.org
Skin acts as the primary interface between the body and the environment. The skin immune
system is composed of a complex network of immune cells and factors that provide the first …

Notch-ing up knowledge on molecular mechanisms of skin fibrosis: focus on the multifaceted Notch signalling pathway

AG Condorelli, M El Hachem, G Zambruno… - Journal of Biomedical …, 2021 - Springer
Fibrosis can be defined as an excessive and deregulated deposition of extracellular matrix
proteins, causing loss of physiological architecture and dysfunction of different tissues and …

Robust temporal map of human in vitro myelopoiesis using single-cell genomics

C Alsinet, MN Primo, V Lorenzi, E Bello, I Kelava… - Nature …, 2022 - nature.com
Myeloid cells are central to homeostasis and immunity. Characterising in vitro myelopoiesis
protocols is imperative for their use in research, immunotherapies, and understanding …

Wound healing across the animal kingdom: crosstalk between the immune system and the extracellular matrix

CM Arenas Gómez, KZ Sabin… - Developmental …, 2020 - Wiley Online Library
Tissue regeneration is widespread in the animal kingdom. To date, key roles for different
molecular and cellular programs in regeneration have been described, but the ultimate …

Mechanotransduction in skin inflammation

MS Shutova, WH Boehncke - Cells, 2022 - mdpi.com
In the process of mechanotransduction, the cells in the body perceive and interpret
mechanical stimuli to maintain tissue homeostasis and respond to the environmental …