COPD immunopathology

G Caramori, P Casolari, A Barczyk, AL Durham… - Seminars in …, 2016 - Springer
The immunopathology of chronic obstructive pulmonary disease (COPD) is based on the
innate and adaptive inflammatory immune responses to the chronic inhalation of cigarette …

Current concepts in targeting chronic obstructive pulmonary disease pharmacotherapy: making progress towards personalised management

PG Woodruff, A Agusti, N Roche, D Singh, FJ Martinez - The Lancet, 2015 - thelancet.com
Chronic obstructive pulmonary disease (COPD) is a common, complex, and heterogeneous
disorder that is responsible for substantial and growing morbidity, mortality, and health-care …

Association of clonal hematopoiesis with chronic obstructive pulmonary disease

PG Miller, D Qiao, J Rojas-Quintero… - Blood, The Journal …, 2022 - ashpublications.org
Chronic obstructive pulmonary disease (COPD) is associated with age and smoking, but
other determinants of the disease are incompletely understood. Clonal hematopoiesis of …

In situ vaccination with cowpea mosaic virus nanoparticles suppresses metastatic cancer

PH Lizotte, AM Wen, MR Sheen, J Fields… - Nature …, 2016 - nature.com
Nanotechnology has tremendous potential to contribute to cancer immunotherapy. The 'in
situ vaccination'immunotherapy strategy directly manipulates identified tumours to overcome …

Electronic cigarette liquid increases inflammation and virus infection in primary human airway epithelial cells

Q Wu, D Jiang, M Minor, HW Chu - PloS one, 2014 - journals.plos.org
Background/Objective The use of electronic cigarettes (e-cigarettes) is rapidly increasing in
the United States, especially among young people since e-cigarettes have been perceived …

MERS-CoV infection is associated with downregulation of genes encoding Th1 and Th2 cytokines/chemokines and elevated inflammatory innate immune response in …

B Alosaimi, ME Hamed, A Naeem, AA Alsharef… - Cytokine, 2020 - Elsevier
MERS-CoV, a highly pathogenic virus in humans, is associated with high morbidity and case
fatality. Inflammatory responses have a significant impact on MERS-CoV pathogenesis and …

Is periodontitis a comorbidity of COPD or can associations be explained by shared risk factors/behaviors?

S Hobbins, ILC Chapple, E Sapey… - International journal of …, 2017 - Taylor & Francis
COPD is recognized as having a series of comorbidities potentially related to common
inflammatory processes. Periodontitis is one of the most common human inflammatory …

[HTML][HTML] Targeted anti-inflammatory therapeutics in asthma and chronic obstructive lung disease

AL Durham, G Caramori, KF Chung, IM Adcock - Translational Research, 2016 - Elsevier
Asthma and chronic obstructive pulmonary disease (COPD) are chronic inflammatory
diseases of the airway, although the drivers and site of the inflammation differ between …

Novel anti-inflammatory approaches to COPD

M Cazzola, NA Hanania, CP Page… - International journal of …, 2023 - Taylor & Francis
Airway inflammation, driven by different types of inflammatory cells and mediators, plays a
fundamental role in COPD and its progression. Neutrophils, eosinophils, macrophages, and …

INKILN is a Novel Long Noncoding RNA Promoting Vascular Smooth Muscle Inflammation via Scaffolding MKL1 and USP10

W Zhang, J Zhao, L Deng, N Ishimwe, J Pauli, W Wu… - Circulation, 2023 - Am Heart Assoc
Background: Activation of vascular smooth muscle cell (VSMC) inflammation is vital to
initiate vascular disease. The role of human-specific long noncoding RNAs in VSMC …