[HTML][HTML] Super-enhancers and their parts: from prediction efforts to pathognomonic status
AV Vasileva, MG Gladkova, GA Ashniev… - International Journal of …, 2024 - mdpi.com
Super-enhancers (SEs) are regions of the genome that play a crucial regulatory role in gene
expression by promoting large-scale transcriptional responses in various cell types and …
expression by promoting large-scale transcriptional responses in various cell types and …
[HTML][HTML] Superenhancers as master gene regulators and novel therapeutic targets in brain tumors
HH Zhuang, Q Qu, XQ Teng, YH Dai, J Qu - Experimental & Molecular …, 2023 - nature.com
Transcriptional deregulation, a cancer cell hallmark, is driven by epigenetic abnormalities in
the majority of brain tumors, including adult glioblastoma and pediatric brain tumors …
the majority of brain tumors, including adult glioblastoma and pediatric brain tumors …
[HTML][HTML] The BRD4 inhibitor JQ1 augments the antitumor efficacy of abemaciclib in preclinical models of gastric carcinoma
M Feng, H Xu, W Zhou, Y Pan - Journal of Experimental & Clinical Cancer …, 2023 - Springer
Background Advanced gastric cancer (GC) is a lethal malignancy, harboring recurrent
alterations in cell cycle pathway, especially the CDKN2A-CDK4/CDK6/CCND1 axis …
alterations in cell cycle pathway, especially the CDKN2A-CDK4/CDK6/CCND1 axis …
Targeting Super-Enhancer-Driven Transcriptional Dependencies Suppresses Aberrant Hedgehog Pathway Activation and Overcomes Smoothened Inhibitor …
Y Sui, T Wang, Y Mei, Y Zhu, W Jiang, J Shen, S Yan… - Cancer Research, 2024 - AACR
Aberrant activation of the Hedgehog (Hh) signaling pathway plays important roles in
oncogenesis and therapeutic resistance in several types of cancer. The clinical application …
oncogenesis and therapeutic resistance in several types of cancer. The clinical application …
Inhibition of inflammation and infiltration of M2 macrophages in NSCLC through the ATF3/CSF1 axis: Role of miR‐27a‐3p
B Zhou, Y Xu, L Xu, Y Kong, K Li… - International Journal of …, 2023 - Wiley Online Library
Non‐small cell lung cancer (NSCLC) imposes a significant economic burden on patients
and society due to its low overall cure and survival rates. Tumour‐associated macrophages …
and society due to its low overall cure and survival rates. Tumour‐associated macrophages …
Single‐cell transcriptomic sequencing identifies subcutaneous patient‐derived xenograft recapitulated medulloblastoma
J Gao, Y Zhao, Z Wang, F Liu, X Chen… - Animal Models and …, 2024 - Wiley Online Library
Background Medulloblastoma (MB) is one of the most common malignant brain tumors that
mainly affect children. Various approaches have been used to model MB to facilitate …
mainly affect children. Various approaches have been used to model MB to facilitate …