Background Delirium is the most common neuropsychiatric syndrome encountered by
clinicians dealing with older adults and the medically ill and is best characterized by 5 core …

Stressful experiences, both physical and psychological, that are overwhelming (ie,
inescapable and unpredictable), can measurably affect subsequent neuronal properties and …

Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …

Glaucoma is a common, complex, multifactorial neurodegenerative disease characterized
by progressive dysfunction and then loss of retinal ganglion cells, the output neurons of the …

Abnormal tau lesions (non-argyrophilic pretangle material, argyrophilic neuropil threads,
neurofibrillary tangles) in select types of neurons are crucial for the pathogenesis of sporadic …

Background Owing to the low therapeutic index of barbiturates, benzodiazepines (BZDs)
became popular in this country and worldwide many decades ago for a wide range of …

The elderly population is growing worldwide, with important health and socioeconomic
implications. Clinical and experimental studies on aging have uncovered numerous …

Age-related cognitive changes often include difficulties in retrieving memories, particularly
those that rely on personal experiences within their temporal and spatial contexts (ie …

Delirium is a neurobehavioral syndrome caused by dysregulation of neuronal activity
secondary to systemic disturbances. Over time, a number of theories have been proposed in …

Conflicting reports about whether adult hippocampal neurogenesis occurs in humans raise
questions about its significance for human health and the relevance of animal models …