Obesity and its comorbidities, including type 2 diabetes mellitus, cardiovascular disease,
heart failure and non-alcoholic liver disease are a major health and economic burden with …

The involvement of cardiovascular disease in cancer onset and development represents a
contemporary interest in basic science. It has been recognized, from the most recent …

Abstract Cysteine dioxygenase 1 (Cdo1) is a key enzyme in taurine synthesis. Here we
show that Cdo1 promotes lipolysis in adipose tissue. Adipose-specific knockout of Cdo1 in …

Exercise is an effective non-pharmacological strategy for ameliorating nonalcoholic fatty
liver disease (NAFLD), but the underlying mechanism needs further investigation. Cysteine …

Energy-dissipating adipocytes have the potential to improve metabolic health. Here, we
identify hypoxia-induced gene domain protein-1a (HIGD1A), a mitochondrial inner …

Background Nonalcoholic fatty liver disease (NAFLD) has emerged as the most common
liver disease. Exercise is an effective strategy against NAFLD, but its underlying molecular …

The benefits of regular physical activity are related to delaying and reversing the onset of
ageing and age-related disorders, including cardiomyopathy, neurodegenerative diseases …

Abstract Cysteine dioxygenase type 1 (CDO1), belonging to the mammalian non-heme Fe
(II) dioxygenases family, is a key enzyme for cysteine catabolism. Its activity and expression …

To elucidate the currently unknown mechanisms responsible for the diverse biological
aspects between two-dimensional (2D) and three-dimensional (3D) cultured 3T3-L1 …

Fibrillin is the major constituent of extracellular microfibrils, which are distributed throughout
connective tissues. Asprosin is derived from the C-terminal region of the FBN1 gene, which …